Crosstalk between non-coding RNAs and programmed cell death in colorectal cancer: implications for targeted therapy.

IF 4.2 2区生物学 Q1 GENETICS & HEREDITY

Epigenetics & Chromatin Pub Date : 2025-01-15 DOI:10.1186/s13072-024-00560-8

Seyed Reza Taha, Mehdi Karimi, Bahar Mahdavi, Milad Yousefi Tehrani, Ali Bemani, Shahriar Kabirian, Javad Mohammadi, Sina Jabbari, Meysam Hushmand, Alireza Mokhtar, Mohammad Hossein Pourhanifeh

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引用次数: 0

Abstract

Background: Colorectal cancer (CRC) remains one of the most common causes of cancer-related mortality worldwide. Its progression is influenced by complex interactions involving genetic, epigenetic, and environmental factors. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), have been identified as key regulators of gene expression, affecting diverse biological processes, notably programmed cell death (PCD).

Objective: This review aims to explore the relationship between ncRNAs and PCD in CRC, focusing on how ncRNAs influence cancer cell survival, proliferation, and treatment resistance.

Methods: A comprehensive literature analysis was conducted to examine recent findings on the role of ncRNAs in modulating various PCD mechanisms, including apoptosis, autophagy, necroptosis, and pyroptosis, and their impact on CRC development and therapeutic response.

Results: ncRNAs were found to significantly regulate PCD pathways, impacting tumor growth, metastasis, and treatment sensitivity in CRC. Their influence on these pathways highlights the potential of ncRNAs as biomarkers for early CRC detection and as targets for innovative therapeutic interventions.

Conclusion: Understanding the involvement of ncRNAs in PCD regulation offers new insights into CRC biology. The targeted modulation of ncRNA-PCD interactions presents promising avenues for personalized cancer treatment, which may improve patient outcomes by enhancing therapeutic effectiveness and reducing resistance.

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结直肠癌非编码rna与程序性细胞死亡之间的串扰：对靶向治疗的影响。

背景：结直肠癌（CRC）仍然是世界范围内最常见的癌症相关死亡原因之一。它的发展受到遗传、表观遗传和环境因素的复杂相互作用的影响。非编码rna (ncRNAs)，包括微rna （miRNAs）、长链非编码rna （lncRNAs）和环状rna (circRNAs)，已被确定为基因表达的关键调控因子，影响多种生物过程，特别是程序性细胞死亡（PCD）。目的：本文旨在探讨结直肠癌中ncRNAs与PCD的关系，重点探讨ncRNAs如何影响癌细胞的存活、增殖和治疗耐药性。方法：通过全面的文献分析，研究了ncRNAs在调节多种PCD机制（包括凋亡、自噬、坏死坏死和焦亡）中的作用，以及它们对CRC发展和治疗反应的影响。结果：发现ncRNAs显著调节PCD通路，影响结直肠癌的肿瘤生长、转移和治疗敏感性。它们对这些通路的影响突出了ncrna作为早期结直肠癌检测的生物标志物和创新治疗干预的靶点的潜力。结论：了解ncRNAs在PCD调控中的作用为CRC生物学提供了新的见解。靶向调节ncRNA-PCD相互作用为个性化癌症治疗提供了有希望的途径，这可能通过提高治疗效果和减少耐药性来改善患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Epigenetics & Chromatin GENETICS & HEREDITY-

CiteScore

7.00

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Epigenetics & Chromatin is a peer-reviewed, open access, online journal that publishes research, and reviews, providing novel insights into epigenetic inheritance and chromatin-based interactions. The journal aims to understand how gene and chromosomal elements are regulated and their activities maintained during processes such as cell division, differentiation and environmental alteration.