Glia: the cellular glue that binds circadian rhythms and sleep.

IF 5.6 2区 医学 Q1 Medicine
Sleep Pub Date : 2025-03-11 DOI:10.1093/sleep/zsae314
Catarina Carvalhas-Almeida, Amita Sehgal
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引用次数: 0

Abstract

Glia are increasingly appreciated as serving an important function in the control of sleep and circadian rhythms. Glial cells in Drosophila and mammals regulate daily rhythms of locomotor activity and sleep as well as homeostatic rebound following sleep deprivation. In addition, they contribute to proposed functions of sleep, with different functions mapping to varied glial subtypes. Here, we discuss recent findings in Drosophila and rodent models establishing a role of glia in circadian or sleep regulation of synaptic plasticity, brain metabolism, removal of cellular debris, and immune challenges. These findings underscore the relevance of glia for benefits attributed to sleep and have implications for understanding the neurobiological mechanisms underlying sleep and associated disorders.

胶质细胞连接昼夜节律和睡眠的细胞粘合剂
神经胶质细胞在控制睡眠和昼夜节律方面起着重要的作用,人们越来越认识到这一点。果蝇和哺乳动物的神经胶质细胞调节运动活动和睡眠的日常节律以及睡眠剥夺后的稳态反弹。此外,它们有助于睡眠的功能,不同的功能映射到不同的神经胶质亚型。在这里,我们讨论了最近在果蝇和啮齿动物模型中发现的神经胶质在突触可塑性、脑代谢、细胞碎片清除和免疫挑战的昼夜节律或睡眠调节中的作用。这些发现强调了神经胶质与睡眠益处的相关性,并对理解睡眠和相关疾病的神经生物学机制具有重要意义。
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来源期刊
Sleep
Sleep Medicine-Neurology (clinical)
CiteScore
8.70
自引率
10.70%
发文量
0
期刊介绍: SLEEP® publishes findings from studies conducted at any level of analysis, including: Genes Molecules Cells Physiology Neural systems and circuits Behavior and cognition Self-report SLEEP® publishes articles that use a wide variety of scientific approaches and address a broad range of topics. These may include, but are not limited to: Basic and neuroscience studies of sleep and circadian mechanisms In vitro and animal models of sleep, circadian rhythms, and human disorders Pre-clinical human investigations, including the measurement and manipulation of sleep and circadian rhythms Studies in clinical or population samples. These may address factors influencing sleep and circadian rhythms (e.g., development and aging, and social and environmental influences) and relationships between sleep, circadian rhythms, health, and disease Clinical trials, epidemiology studies, implementation, and dissemination research.
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