Associations of Th1, Th2, Th17, and Treg cell levels and imbalance with recurrent spontaneous abortion: A meta-analysis

IF 1.6 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research Pub Date : 2025-01-15 DOI:10.1111/jog.16207

Yuan Li, Shuxia Chen, Jiecheng Yang, Kejuan Zhang, Xin Feng, Chao Sun, Qiang Feng, Zhe Li

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引用次数: 0

Abstract

Objective

Abnormal levels and imbalances of T cell subsets are common in recurrent spontaneous abortion (RSA) patients, but most studies have small sample sizes, and comprehensive evaluations are lacking. Therefore, this meta-analysis aimed to comprehensively investigate T cell subsets and their ratios in RSA patients.

Methods

Four databases (PubMed, EMBASE, Web of Science, and Cochrane Library databases) were searched until 10 January 2024. T helper 1 (Th1), Th2, Th1/Th2 ratio, Th17, regulatory T (Treg), Treg/Th17 ratio, and the correlation between Th17 and Treg were considered endpoint indexes.

Results

Twenty-six studies involving 1143 RSA women (RSA group) and 863 healthy women (healthy control group) were included. Th1 (standardized mean difference [SMD] = 0.603%; 95% confidence intervals [CI]: 0.406%, 0.800%; p < 0.001), Th1/Th2 ratio (SMD = 0.838; 95% CI: 0.364, 1.312; p = 0.001), and Th17 (SMD = 1.047%; 95% CI: 0.734%, 1.360%; p < 0.001) increased; Th2 (SMD = −0.719%; 95% CI: −1.263%, −0.174%; p = 0.010), Treg (SMD = −1.176%; 95% CI: −1.755%, −0.596%; p < 0.001) and Treg/Th17 ratio (SMD = −0.978; 95% CI: −1.576, −0.381; p = 0.001) reduced in RSA group versus healthy control group. Th17 were inversely correlated with Treg in RSA patients (Correlation coefficient = −0.488; 95% CI: −0.726, −0.145; p = 0.019). The risk of bias was relatively low. There was no publication bias for Th1, Th2, or Th1/Th2 ratio; publication biases for other outcomes were corrected by the trim-and-fill method. Sensitivity analyses showed relatively high robustness.

Conclusion

Th1, Th1/Th2 ratio, and Th17 are elevated, while Th2, Treg, and Treg/Th17 ratio are reduced in RSA patients. Meanwhile, Th17 was inversely correlated with Treg in these patients.

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Th1、Th2、Th17和Treg细胞水平和失衡与复发性自然流产的关系：一项荟萃分析

目的：T细胞亚群水平异常和失衡在复发性自然流产（RSA）患者中很常见，但大多数研究样本量小，缺乏全面的评估。因此，本荟萃分析旨在全面研究RSA患者的T细胞亚群及其比例。方法：检索PubMed、EMBASE、Web of Science和Cochrane Library数据库，检索时间截止到2024年1月10日。辅助T 1 （Th1）、Th2、Th1/Th2比值、Th17、调节性T （Treg）、Treg/Th17比值、Th17与Treg的相关性作为终点指标。结果：纳入26项研究，共1143名RSA女性（RSA组）和863名健康女性（健康对照组）。Th1(标准化均差[SMD] = 0.603%；95%置信区间[CI]: 0.406%, 0.800%；p结论：RSA患者Th1、Th1/Th2比值、Th17升高，Th2、Treg、Treg/Th17比值降低。同时，在这些患者中，Th17与Treg呈负相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Obstetrics and Gynaecology Research 医学-妇产科学

CiteScore

3.10

自引率

0.00%

发文量

376

审稿时长

3-6 weeks

期刊介绍： The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.