Association between traffic-related air pollution and risk of outpatient visits for dry eye disease in a megacity along the subtropical coast in South China.

IF 3.5 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Fan Cao, Yue Chen, Yan-Chao Gui, Zi-Yue Fu, Zheng Lyu, Kou Liu, Li-Ming Tao, Zhi-Fan Chen, Hai-Feng Pan, Zheng-Xuan Jiang, Qian-Li Meng
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引用次数: 0

Abstract

Background: Traffic-related air pollution especially in highly socioeconomically developed megacity is usually considered as a severe problem leading to inevitable adverse health outcomes. This study aimed to investigate the associations between traffic-related air pollutants with risk of dry eye disease (DED) outpatient visits in a megacity (Guangzhou) along the subtropical coast in South China.

Methods: Daily data on DED outpatient visits and environmental variables from 1 January 2014 to 31 December 2020 in Guangzhou were obtained. A time-series study using a quasi-Poisson generalized linear model (GLM) combined with distributed lag non-linear model (DLNM) was adopted. Subgroup analyses stratified by age, gender, and season were conducted.

Results: Totally, 27, 828 DED cases were identified during the study period including 2557 days. Daily number of outpatient visits for DED ranged from 0 to 41. An increase of 10 μg/m3 in PM2.5, NO2 and SO2 concentration was associated with 3.1%, 5.9% and 17.4% increase in the risk of DED outpatient visits, respectively (RRPM2.5 = 1.031, 95%CI: 1.004-1.059, lag 0-11 day; RRNO2 = 1.059, 95% CI: 1.027-1.092, lag0-14 day; RRSO2 = 1.174, 95% CI: 1.036-1.330, lag0-13 day). Subgroup analyses indicated that the effects of PM2.5 exposure on the risk of DED outpatient visits remained significant in aged < 60 years (RR max = 1.008, 95% CI: 1.003-1.013, lag0 day) and the effects of SO2 exposure on the DED outpatient visits risk remained significant in the females (RR max = 1.025, 95% CI: 1.006-1.044, lag0 day). The associations of PM2.5 (RR = 1.010, 95% CI: 1.003-1.016, lag0 day) and SO2 (RR = 1.030, 95% CI: 1.003-1.058, lag14 day) exposure with DED outpatient visits risk remained significant in warm seasons, whereas NO2 (RR = 1.006, 95% CI: 1.002-1.009, lag14 day) exposure was significantly associated with DED outpatient visits in cold seasons. The associations of PM2.5 (first visit, RR = 1.006, 95% CI: 1.001-1.011, lag0 day; re-visit, RR = 1.002, 95% CI: 1.000-1.005, lag6 day), NO2 (first visit, RR = 1.006, 95% CI: 1.001-1.012, lag0 day; re-visit, RR = 1.007, 95% CI: 1.002-1.012, lag0 day), and SO2 (first visit, RR = 1.023, 95% CI: 1.002-1.044, lag0 day; re-visit, RR = 1.023, 95% CI: 1.000-1.045, lag0 day) exposure with risk of DED outpatient visits were significant for both first- and re-visits.

Conclusions: Our study revealed that short-term exposure to PM2.5, NO2 and SO2 were positively associated with risk of DED outpatient visits, especially for the youngers, females and during warm seasons, providing evidence for making public health policy to improve life quality in developed megacity.

华南亚热带沿海某特大城市交通相关空气污染与干眼病门诊就诊风险之间的关系
背景:与交通有关的空气污染,特别是在社会经济高度发达的大城市,通常被认为是导致不可避免的不良健康后果的严重问题。本研究旨在调查华南亚热带沿海大城市(广州)交通相关空气污染物与干眼病(DED)门诊就诊风险之间的关系。方法:获取广州市2014年1月1日至2020年12月31日每日DED门诊就诊数据和环境变量。采用拟泊松广义线性模型(GLM)与分布滞后非线性模型(DLNM)相结合的时间序列研究。按年龄、性别和季节分层进行亚组分析。结果:在2557天的研究期间,共发现27828例DED病例。DED的每日门诊次数为0 ~ 41次。PM2.5、NO2和SO2浓度每增加10 μg/m3, DED门诊就诊风险分别增加3.1%、5.9%和17.4% (RRPM2.5 = 1.031, 95%CI: 1.004 ~ 1.059,滞后期0 ~ 11 d;RRNO2 = 1.059, 95% CI: 1.027 ~ 1.092, lag0 ~ 14天;RRSO2 = 1.174, 95% CI: 1.036—-1.330,lag0-13天)。亚组分析显示,PM2.5暴露对老年人DED门诊就诊风险的影响仍然显著(max = 1.008, 95% CI: 1.003-1.013, lag0 day), SO2暴露对女性DED门诊就诊风险的影响仍然显著(RR max = 1.025, 95% CI: 1.006-1.044, lag0 day)。PM2.5 (RR = 1.010, 95% CI: 1.003-1.016, lag0 d)和SO2 (RR = 1.030, 95% CI: 1.003-1.058, lag14 d)暴露与DED门诊就诊风险在温暖季节仍然显著相关,而NO2 (RR = 1.006, 95% CI: 1.002-1.009, lag14 d)暴露与DED门诊就诊风险在寒冷季节显著相关。PM2.5的相关性(首次访视,RR = 1.006, 95% CI: 1.001 ~ 1.011, lag0天;再次就诊,RR = 1.002, 95% CI: 1.000-1.005, lag6天),NO2(首次就诊,RR = 1.006, 95% CI: 1.001-1.012, lag0天;复诊,RR = 1.007, 95% CI: 1.002-1.012, lag0天)和SO2(首次就诊,RR = 1.023, 95% CI: 1.002-1.044, lag0天;再次就诊,RR = 1.023, 95% CI: 1.000-1.045, lag0天)暴露与DED门诊就诊的风险在首次和再次就诊中均具有显著性。结论:我们的研究表明,PM2.5、NO2和SO2的短期暴露与DED门诊就诊风险呈正相关,特别是在年轻人、女性和温暖季节,为制定改善发达大城市生活质量的公共卫生政策提供了证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMC Public Health
BMC Public Health 医学-公共卫生、环境卫生与职业卫生
CiteScore
6.50
自引率
4.40%
发文量
2108
审稿时长
1 months
期刊介绍: BMC Public Health is an open access, peer-reviewed journal that considers articles on the epidemiology of disease and the understanding of all aspects of public health. The journal has a special focus on the social determinants of health, the environmental, behavioral, and occupational correlates of health and disease, and the impact of health policies, practices and interventions on the community.
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