Epidemiology of ophthalmia neonatorum: a systematic review and meta-analysis.

IF 2 3区医学 Q2 PEDIATRICS

BMC Pediatrics Pub Date : 2025-01-14 DOI:10.1186/s12887-024-05382-x

Randy Asiamah, Gideon Owusu, Pious Tawiah Amoako, Richmond Amponsah, Emmanuel Adator, Samuel Kyei

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引用次数: 0

Abstract

Purpose: To elucidate the global epidemiology of Ophthalmia Neonatorum (ON), as well as its causative organisms and their antibiotic susceptibility patterns.

Methods: A systematic review of studies reporting the epidemiology of ON was performed using four electronic databases: PubMed, Scopus, Web of Science, and Medline. Data were extracted and study-specific estimates were combined using meta-analysis to obtain pooled proportions.

Results: A total of 25 studies, which evaluated the epidemiology of ON in 1,117,966 live births, were included in this study. A total of 2,902 cases of ON were identified. The global incidence and prevalence of ON are 2.04% [(95% CI 0.70-5.79%), I² = 99.4%] and 7.79% [(95% CI 2.93-19.10%), I² = 99.1%], respectively. Staphylococcus spp. (gram-positive) and Serratia marcescens (gram-negative) were the most frequently isolated bacteria associated with the incidence of ON. The pooled resistance of Staphylococcus aureus and Escherichia coli are highest to Penicillin [91.67% (95% CI 87.96-94.31%) and 100.00% (95% CI 0.00-100.00%), respectively], and lowest to Gentamicin [20% (95% CI 15.85-24.91%) and 59.30% (95% CI 52.36-65.89%), respectively]. The pooled resistance of Pseudomonas spp. and Klebsiella spp. to Gentamicin are 50% [(95% CI 43.11 to 56.89%), I² = 0.00%] and 50.02% [(95% CI 27.50-72.53%), I² = 95.3%], respectively.

Conclusion: ON is a common ocular morbidity in neonates, especially in those from low-income settings. It is important that all newborns receive adequate preventive care, regardless of their socioeconomic status, in order to reduce the risk of visual impairment and blindness.

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新生儿眼炎的流行病学：系统回顾和荟萃分析。

目的：了解新生儿眼炎（ophthalatorium Neonatorum， ON）的全球流行病学、病原菌及其药敏模式。方法：使用PubMed、Scopus、Web of Science和Medline四个电子数据库对报道ON流行病学的研究进行系统综述。提取数据并使用meta分析合并特定研究的估计值以获得合并比例。结果：本研究共纳入25项研究，评估了1,117,966例活产婴儿的ON流行病学。共发现ON 2902例。全球ON的发病率和患病率分别为2.04% [(95% CI 0.70-5.79%), I2 = 99.4%]和7.79% [(95% CI 2.93-19.10%), I2 = 99.1%]。葡萄球菌（革兰氏阳性）和粘质沙雷氏菌（革兰氏阴性）是与ON发病率相关的最常见分离细菌。金黄色葡萄球菌和大肠杆菌对青霉素的总耐药性最高[分别为91.67% （95% CI 87.96 ~ 94.31%）和100.00% (95% CI 0.00% ~ 100.00%)]，对庆大霉素的总耐药性最低[分别为20% （95% CI 15.85 ~ 24.91%）和59.30% (95% CI 52.36 ~ 65.89%)]。假单胞菌和克雷伯菌对庆大霉素的总耐药率分别为50% [(95% CI 43.11 ~ 56.89%), I2 = 0.00%]和50.02% [(95% CI 27.50 ~ 72.53%), I2 = 95.3%]。结论：ON是新生儿常见的眼部疾病，尤其是低收入家庭。重要的是，无论其社会经济地位如何，所有新生儿都应获得适当的预防性保健，以减少视力损害和失明的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Pediatrics PEDIATRICS-

CiteScore

3.70

自引率

4.20%

发文量

683

审稿时长

3-8 weeks

期刊介绍： BMC Pediatrics is an open access journal publishing peer-reviewed research articles in all aspects of health care in neonates, children and adolescents, as well as related molecular genetics, pathophysiology, and epidemiology.