Chemical and Enzymatic Mechanosynthesis of Organocatalytic Peptide Materials Based on Proline and Phenylalanine.

IF 7.5 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
ChemSusChem Pub Date : 2025-01-15 DOI:10.1002/cssc.202402446
Alexandra Rios-Echeverri, Carlos E Puerto Galvis, Karen J Ardila-Fierro, José G Hernández
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引用次数: 0

Abstract

In recent years, mechanosynthesis of peptides through either chemical or enzymatic routes has been accomplished. In part, this advancement has been driven due to the organocatalytic properties of peptide-based biomaterials. In this work, we report the merging of chemical and enzymatic protocols under mechanochemical conditions to synthesize peptide materials based on L-proline and L-phenylalanine. Compared to traditional step-by-step peptide synthesis in solution, our mechanochemical approach combining peptide coupling reagents with the proteolytic enzyme papain offers a more sustainable route by reducing the number of synthetic steps, shortening reaction times, increasing chemical yields, and minimizing waste production. Notably, the mechanosynthesized peptides exhibited organocatalytic activity in the asymmetric aldol reaction between cyclohexanone and 4-nitrobenzaldehyde.

基于脯氨酸和苯丙氨酸的有机催化多肽材料的化学和酶的机械合成。
近年来,通过化学或酶的途径完成了多肽的机械合成。在某种程度上,这一进步是由于肽基生物材料的有机催化特性而推动的。在这项工作中,我们报道了在机械化学条件下结合化学和酶的方案合成基于l -脯氨酸和l -苯丙氨酸的肽材料。与传统的一步一步在溶液中合成肽相比,我们的机械化学方法将肽偶联试剂与蛋白水解酶木瓜蛋白酶结合,通过减少合成步骤,缩短反应时间,提高化学产量,并最大限度地减少废物产生,提供了一种更可持续的途径。值得注意的是,机械合成的多肽在环己酮和4-硝基苯甲醛的不对称醛醇反应中表现出有机催化活性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ChemSusChem
ChemSusChem 化学-化学综合
CiteScore
15.80
自引率
4.80%
发文量
555
审稿时长
1.8 months
期刊介绍: ChemSusChem Impact Factor (2016): 7.226 Scope: Interdisciplinary journal Focuses on research at the interface of chemistry and sustainability Features the best research on sustainability and energy Areas Covered: Chemistry Materials Science Chemical Engineering Biotechnology
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