Targeted Therapeutics in Oncology and Neurology: Advances in Kinase Inhibition and Biomarkers for Brain Injury.

IF 3.5 3区医学 Q2 CHEMISTRY, MEDICINAL

ACS Medicinal Chemistry Letters Pub Date : 2024-12-18 eCollection Date: 2025-01-09 DOI:10.1021/acsmedchemlett.4c00585

Robert B Kargbo

引用次数: 0

Abstract

Innovations in pharmaceutical science drive new treatment approaches for cancer and brain injury. This Patent Highlight reviews findings from three patents focused on kinase inhibition in cancer therapy and using biomarkers to assess brain injury. By targeting key enzymes such as AKT1 and diacylglycerol kinase alpha (DGKα), these innovations offer new strategies for cancer treatment, particularly in cases of resistance to conventional therapies. In parallel, advances in biomarker-based diagnostics provide a more sensitive means of detecting traumatic brain injuries (TBI). Together, these breakthroughs hold promise for improving outcomes in oncology and neurology.

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肿瘤和神经学的靶向治疗：脑损伤的激酶抑制和生物标志物研究进展。

制药科学的创新推动了癌症和脑损伤的新治疗方法。本专利重点综述了三项专利的发现，这些专利集中在癌症治疗中的激酶抑制和使用生物标志物评估脑损伤。通过靶向关键酶，如AKT1和二酰基甘油激酶α (DGKα)，这些创新为癌症治疗提供了新的策略，特别是在对传统疗法产生耐药性的情况下。与此同时，基于生物标志物的诊断技术的进步为检测创伤性脑损伤（TBI）提供了更灵敏的方法。总之，这些突破有望改善肿瘤学和神经学的治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Medicinal Chemistry Letters CHEMISTRY, MEDICINAL-

CiteScore

7.30

自引率

2.40%

发文量

328

审稿时长

1 months

期刊介绍： ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to: Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics) Biological characterization of new molecular entities in the context of drug discovery Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc. Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic Mechanistic drug metabolism and regulation of metabolic enzyme gene expression Chemistry patents relevant to the medicinal chemistry field.