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{"title":"New Multiomic Studies Shed Light on Cellular Diversity and Neuronal Susceptibility in Parkinson's Disease","authors":"Marianna Liang BS, Linh Chu BA, Zhenyu Yue PhD","doi":"10.1002/mds.30097","DOIUrl":null,"url":null,"abstract":"<p>Parkinson's disease is a complex neurodegenerative disorder characterized by degeneration of dopaminergic neurons, with patients manifesting varying motor and nonmotor symptoms. Previous studies using single-cell RNA sequencing in rodent models and humans have identified distinct heterogeneity of neurons and glial cells with differential vulnerability. Recent studies have increasingly leveraged multiomics approaches, including spatial transcriptomics, epigenomics, and proteomics, in the study of Parkinson's disease, providing new insights into pathogenic mechanisms. Continued advancements in experimental technologies and sophisticated computational tools will be essential in uncovering a network of neuronal vulnerability and prioritizing disease modifiers for novel therapeutics development. © 2025 International Parkinson and Movement Disorder Society.</p>","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"40 3","pages":"431-437"},"PeriodicalIF":7.4000,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Movement Disorders","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/mds.30097","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
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Abstract
Parkinson's disease is a complex neurodegenerative disorder characterized by degeneration of dopaminergic neurons, with patients manifesting varying motor and nonmotor symptoms. Previous studies using single-cell RNA sequencing in rodent models and humans have identified distinct heterogeneity of neurons and glial cells with differential vulnerability. Recent studies have increasingly leveraged multiomics approaches, including spatial transcriptomics, epigenomics, and proteomics, in the study of Parkinson's disease, providing new insights into pathogenic mechanisms. Continued advancements in experimental technologies and sophisticated computational tools will be essential in uncovering a network of neuronal vulnerability and prioritizing disease modifiers for novel therapeutics development. © 2025 International Parkinson and Movement Disorder Society.
新的多组学研究揭示了帕金森病的细胞多样性和神经元易感性。
帕金森病是一种以多巴胺能神经元变性为特征的复杂神经退行性疾病，患者表现出不同的运动和非运动症状。先前在啮齿动物模型和人类中使用单细胞RNA测序的研究已经确定了具有不同易损性的神经元和神经胶质细胞的明显异质性。最近的研究越来越多地利用多组学方法，包括空间转录组学、表观基因组学和蛋白质组学，在帕金森病的研究中，为致病机制提供了新的见解。实验技术和复杂计算工具的持续进步对于揭示神经易感性网络和优先考虑疾病调节剂以开发新的治疗方法至关重要。©2025国际帕金森和运动障碍学会。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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