Increased cardiovascular risk despite unchanged body composition in non functional adrenal incidentaloma

IF 2.9 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Annales d'endocrinologie Pub Date : 2025-01-11 DOI:10.1016/j.ando.2025.101687

Alperen Boyraz , Burcu Candemir , Şafak Akın , Mustafa Candemir , Neşe Ersöz Gülçelik

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引用次数: 0

Abstract

Background

Non-functional adrenal incidentaloma (NFAI) is associated with an increased risk of adverse cardiometabolic outcome. Identifying predictors of atherosclerotic cardiovascular disease (ASCVD) may enable more appropriate management strategies in patients with NFAI. We aimed to investigate the body composition parameters and ASCVD risk in patients with NFAI.

Methods

Eighty patients with NFAI and 80 controls matched for age, gender and body mass index (BMI) were included. ASCVD risk was assessed on Framingham Risk Score (FRS) and American Heart Association/American College of Cardiology (AHA/ACC) score. Body composition was evaluated using a segmental body composition analyzer.

Results

There were no significant differences in age, gender, blood pressure or body composition parameters between the two groups. Patients with NFAI had higher FRS and AHA/ACC scores than controls (P = 0.017, P = 0.024, respectively). In patients with NFAI, independent predictors for FRS were serum cortisol level after 1 mg dexamethasone suppression test (DST) and waist/hip ratio (WHR), while independent predictors for AHA/ACC score were serum cortisol level after 1 mg DST, WHR and fasting plasma glucose (FPG), in various multivariate linear regression models.

Conclusions

FRS and AHA/ACC scores may be useful in determining ASCVD risk in patients with NFAI, and serum cortisol level after 1 mg DST is an independent predictor of ASCVD in these patients, even in the absence of hypercortisolism.

查看原文本刊更多论文

NFAI患者尽管身体成分不变，但心血管风险增加。

背景：非功能性肾上腺偶发瘤（NFAI）与不良心脏代谢结果的风险增加相关。确定动脉粥样硬化性心血管疾病（ASCVD）的预测因子可以为NFAI患者提供更合适的管理策略。我们的目的是研究NFAI患者的身体成分参数和ASCVD风险。方法：纳入80例NFAI患者和80例年龄、性别、体重指数（BMI）相匹配的对照组。采用Framingham风险评分（FRS）和美国心脏协会/美国心脏病学会（AHA/ACC）评分评估ASCVD风险。采用节段体成分分析仪评估体成分。结果：两组患者在年龄、性别、血压、体成分等指标上无明显差异。NFAI患者的FRS和AHA/ACC评分高于对照组（p=0.017, p=0.024）。在不同的多元线性回归模型中，NFAI患者FRS的独立预测因子是地塞米松抑制试验（DST）后1 mg血清皮质醇水平和腰臀比（WHR），而AHA/ACC评分的独立预测因子是地塞米松抑制试验（DST）后1 mg血清皮质醇水平、WHR和空腹血糖（FPG）。结论：FRS和AHA/ACC评分可能有助于确定NFAI患者的ASCVD风险，即使在没有高皮质醇血症的情况下，1mg DST后的血清皮质醇水平也是这些患者ASCVD的独立预测因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annales d'endocrinologie 医学-内分泌学与代谢

CiteScore

4.40

自引率

6.50%

发文量

311

审稿时长

50 days

期刊介绍： The Annales d''Endocrinologie, mouthpiece of the French Society of Endocrinology (SFE), publishes reviews, articles and case reports coming from clinical, therapeutic and fundamental research in endocrinology and metabolic diseases. Every year, it carries a position paper by a work-group of French-language endocrinologists, on an endocrine pathology chosen by the Society''s Scientific Committee. The journal is also the organ of the Society''s annual Congress, publishing a summary of the symposia, presentations and posters. "Les Must de l''Endocrinologie" is a special booklet brought out for the Congress, with summary articles that are always very well received. And finally, we publish the high-level instructional courses delivered during the Henri-Pierre Klotz International Endocrinology Days. The Annales is a window on the world, keeping alert clinicians up to date on what is going on in diagnosis and treatment in all the areas of our specialty.