Knee joint extension limitation in female patients with knee osteoarthritis affects the infrapatellar fat pad hardness and hemoglobin concentration by isometric quadriceps exercise

Osteoarthritis and cartilage open Pub Date : 2024-12-11 DOI:10.1016/j.ocarto.2024.100559

Syoya Nakanishi , Masahiro Tsutsumi , Takashi Kitagawa , Toshinori Miyashita , Makoto Wada , Shintarou Kudo

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Abstract

Objective

To investigate whether there is a difference in hardness and hemoglobin concentration changes in the infrapatellar fat pad (IFP) during isometric quadriceps exercise (IQE) in patients with knee osteoarthritis (KOA) between those with and without knee extension limitation.

Design

In this cross-sectional study, data were collected at an orthopedic clinic from March 2022 to April 2023. Among patients diagnosed with KOA, those with knee joint extension range of motion <0° and >0° were defined as the limited group (n = 16) and non-limited group (n = 13), respectively. Ultrasonography was performed at rest and during IQE to measure IFP hardness based on shear wave velocity. Near-infrared spectroscopy was performed to measure oxygenated hemoglobin (O2Hb), deoxygenated hemoglobin (HHb), and total hemoglobin (cHb) in the IFP before (baseline), during (IQE task), and post IQE. IFP hardness and O2Hb, HHb, and cHb concentration were analyzed using a linear mixed model for the groups and measurement points.

Results

IFP hardness changes during IQE were significantly less in the limited group than in the non-limited group (limited: mean difference [MD] = −0.136, 95 % confidence interval [CI] [−0.475, 0.203]; non-limited: MD = −1.154, 95 % CI [−1.530, −0.778]). O2Hb concentration did not significantly change at post compared with baseline in the limited group but did in the non-limited group (limited: MD = −0.024, 95 % CI [−0.961, 0.913]; non-limited: MD = −4.118, 95 % CI [−5.156, −3.079]).

Conclusions

The limited group revealed no IFP hardness and hemoglobin concentration change following IQE, whereas the opposite was observed for the non-limited group, indicating oxygenation.

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女性膝关节骨性关节炎患者膝关节伸展受限对等长股四头肌运动对髌下脂肪垫硬度和血红蛋白浓度的影响。

目的：探讨膝盖骨关节炎（KOA）患者行等长股四头肌运动（IQE）时，髌下脂肪垫（IFP）硬度及血红蛋白浓度变化是否存在差异。设计：在这项横断面研究中，数据收集于2022年3月至2023年4月在一家骨科诊所。在确诊为KOA的患者中，将膝关节伸展活动范围为0°的患者分别定义为受限组（n = 16）和非受限组（n = 13）。在静止和IQE期间进行超声检查以测量基于剪切波速的IFP硬度。采用近红外光谱法测量IFP在IQE前（基线）、IQE任务期间和IQE后的氧合血红蛋白（O2Hb）、脱氧血红蛋白（hbb）和总血红蛋白（cHb）。采用组和测点的线性混合模型分析IFP硬度和O2Hb、hbb和cHb浓度。结果：IQE期间，限制组IFP硬度变化明显小于非限制组(限制：平均差[MD] = -0.136, 95%可信区间[CI] [-0.475, 0.203]；是非:MD = -1.154, 95% CI[-1.530, -0.778])。与基线相比，限制组术后O2Hb浓度无显著变化，而非限制组有显著变化(限制：MD = -0.024, 95% CI [-0.961, 0.913]；是非:MD = -4.118, 95% CI[-5.156, -3.079])。结论：限制组IQE后IFP硬度和血红蛋白浓度无变化，非限制组则相反，提示有氧合作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Osteoarthritis and cartilage open Orthopedics, Sports Medicine and Rehabilitation

CiteScore

3.30

自引率

0.00%

发文量