Prevalence of congenital heart defects in people with Down syndrome: a systematic review and meta-analysis.

IF 4.9 2区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Journal of Epidemiology and Community Health Pub Date : 2025-01-13 DOI:10.1136/jech-2023-220638

Chen-Xi Xu, Lei Chen, Yong Cheng, Yang Du

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引用次数: 0

Abstract

Background: The prevalence of congenital heart defects (CHD) in Down syndrome (DS) varies considerably across studies (from 16% to 84%). This study aimed to estimate the prevalence of CHD in people with DS (CHD-DS).

Methods: PubMed, Web of Science and the Chinese National Knowledge Infrastructure databases were searched through to 5 January 2023. English-language and Chinese-language articles reporting data on the prevalence of CHD in people with DS were included. Two independent observers performed data extraction and we used a random effects model for all statistical analyses by the Comprehensive Meta-Analysis V.3.3.070 software.

Results: A pooled analysis, based on 102 studies that included 60 610 individuals, revealed the prevalence of CHD was 49.9% (95% CI: 46.8% to 53.0%) in people with DS. Most of the studies included in this meta-analysis were from North America, Europe and Asia, and subgroup analyses showed a slightly higher prevalence of CHD-DS in Asia (27 studies) compared with North America (28 studies) and Europe (35 studies) (Asia vs North America vs Europe; 54.2% vs 51.6% vs 46.2%).

Conclusion: These results demonstrated that approximately one-half of people with DS had CHD, reinforcing the need to screen all newborns suspected of Down syndrome for CHD.

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唐氏综合症患者先天性心脏缺陷的患病率：一项系统回顾和荟萃分析。

背景：唐氏综合征（DS）中先天性心脏缺陷（CHD）的患病率在研究中差异很大（从16%到84%）。本研究旨在估计冠心病患者（冠心病）的患病率。方法：检索截至2023年1月5日的PubMed、Web of Science和Chinese National Knowledge Infrastructure数据库。纳入了报告DS患者冠心病患病率数据的英文和中文文章。2名独立观察员进行数据提取，所有统计分析采用随机效应模型，采用综合meta分析V.3.3.070软件。结果：一项基于102项研究，包括60610人的汇总分析显示，DS患者的冠心病患病率为49.9% （95% CI: 46.8%至53.0%）。本荟萃分析中纳入的大多数研究来自北美、欧洲和亚洲，亚组分析显示，亚洲（27项研究）的冠心病患病率略高于北美（28项研究）和欧洲（35项研究）(亚洲vs北美vs欧洲；54.2% vs 51.6% vs 46.2%)。结论：这些结果表明，大约一半的唐氏综合征患者患有冠心病，这加强了对所有怀疑患有唐氏综合征的新生儿进行冠心病筛查的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Epidemiology and Community Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

11.10

自引率

0.00%

发文量

100

审稿时长

3-6 weeks

期刊介绍： The Journal of Epidemiology and Community Health is a leading international journal devoted to publication of original research and reviews covering applied, methodological and theoretical issues with emphasis on studies using multidisciplinary or integrative approaches. The journal aims to improve epidemiological knowledge and ultimately health worldwide.