Efficacy of Split-Thickness Thin Amniotic Membrane Graft for Closure of Refractory or Large Macular Holes.

IF 2.3 2区医学 Q2 OPHTHALMOLOGY

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-01-07 DOI:10.1097/IAE.0000000000004399

Vichar Trivedi, Qisheng You, Patrick Sy Lee, Jacob Im, David V Tran, Rao Me, Brian Benenati, Andrew Gregory, Kim Le, Xihui Lin

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Abstract

Purpose: To assess the effectiveness of split-thickness amniotic membrane (SAM) grafts in achieving closure of refractory or large macular holes (MH).

Methods: This retrospective study reviewed data from patients who underwent surgical repair of MHs using SAM grafts between January 2019 and December 2023. Key parameters, including best-corrected visual acuity (BCVA) and MH size, were evaluated both preoperatively and postoperatively.

Results: The study included 13 patients (9 females; mean age 63.5 years). Before surgery, the median BCVA was 1.30 ± 0.56 LogMAR (approximate Snellen equivalent: 20/400), and the median MH size measured 717 ± 246.6 µm. After an average follow-up period of 28 months, the median BCVA improved significantly to 1.00 ± 0.52 LogMAR (p < 0.05) (approximate Snellen equivalent: 20/200). All MHs were successfully closed, and no intraoperative complications were observed.

Conclusion: SAM grafting is a safe and reliable option for closing refractory or large MHs, resulting in significant improvements in BCVA and successful hole closure. Compared to full-thickness grafts, SAM grafts offer advantages such as increased flexibility in placement and ease of removal post-closure, due to their thinner and more pliable nature, which facilitates easier handling and positioning within the MH.

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分厚薄羊膜移植治疗难治性黄斑大孔的疗效观察。

目的：评价分厚羊膜（SAM）移植治疗难治性或大黄斑孔（MH）的疗效。方法：本回顾性研究回顾了2019年1月至2023年12月期间使用SAM移植物进行mhh手术修复的患者的数据。术前、术后评估最佳矫正视力（BCVA）、MH大小等关键参数。结果：纳入13例患者(女性9例；平均年龄63.5岁)。术前中位BCVA为1.30±0.56 LogMAR（近似Snellen当量：20/400），中位MH尺寸为717±246.6µm。平均随访28个月后，中位BCVA显著改善至1.00±0.52 LogMAR (p < 0.05)（近似Snellen当量：20/200）。所有mhh均成功闭合，无术中并发症。结论：SAM植入术是一种安全可靠的治疗顽固性或大MHs的方法，可显著改善BCVA并成功闭合孔。与全厚度移植物相比，SAM移植物的优点在于其更薄、更柔韧，更容易在MH内处理和定位，因此在放置时更灵活，关闭后更容易移除。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Retina-The Journal of Retinal and Vitreous Diseases 医学-眼科学

CiteScore

5.70

自引率

9.10%

发文量

554

审稿时长

3-6 weeks

期刊介绍： RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice. In addition to regular reports from clinical and basic science investigators, RETINA® publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards. Issues are abundantly illustrated in vivid full color. Published 12 times per year, RETINA® is truly a “must have” publication for anyone connected to this field.