Staphylococcus aureus: Dynamics of pathogenicity and antimicrobial-resistance in hospital and community environments - Comprehensive overview.

IF 2.5 4区生物学 Q3 MICROBIOLOGY

Research in microbiology Pub Date : 2025-01-11 DOI:10.1016/j.resmic.2025.104267

Giorgio Silva-Santana

引用次数: 0

Abstract

This study reviews Staphylococcus aureus, a significant pathogen in both hospital and community-acquired infections, addressing its epidemiology, pathogenesis, and antimicrobial resistance. It highlights virulence mechanisms, such as adhesion factors, toxins, enzymes, and biofilms, which contribute to survival and immune evasion. The spread of resistance occurs through the transfer of mobile genetic elements like SCCmec and genetic mutations. The analysis also compares hospital and community strains, including multidrug-resistant lineages like MRSA, VISA, and VRSA. The study concludes that S. aureus presents a major public health challenge, requiring new therapeutic approaches and preventive strategies.

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金黄色葡萄球菌：医院和社区环境中致病性和抗菌药耐药性的动态 - 综合概述。

本研究综述了金黄色葡萄球菌这一在医院和社区获得性感染中的重要病原体，阐述了其流行病学、发病机制和抗微生物药物耐药性。它强调了毒力机制，如粘附因子、毒素、酶和生物膜，它们有助于生存和免疫逃避。抗性的传播是通过SCCmec等可移动遗传元素的转移和基因突变发生的。该分析还比较了医院和社区菌株，包括耐多药谱系，如MRSA、VISA和VRSA。该研究得出结论，金黄色葡萄球菌提出了一个重大的公共卫生挑战，需要新的治疗方法和预防策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Research in microbiology 生物-微生物学

CiteScore

4.10

自引率

3.80%

发文量

审稿时长

16 days

期刊介绍： Research in Microbiology is the direct descendant of the original Pasteur periodical entitled Annales de l''Institut Pasteur, created in 1887 by Emile Duclaux under the patronage of Louis Pasteur. The Editorial Committee included Chamberland, Grancher, Nocard, Roux and Straus, and the first issue began with Louis Pasteur''s "Lettre sur la Rage" which clearly defines the spirit of the journal:"You have informed me, my dear Duclaux, that you intend to start a monthly collection of articles entitled "Annales de l''Institut Pasteur". You will be rendering a service that will be appreciated by the ever increasing number of young scientists who are attracted to microbiological studies. In your Annales, our laboratory research will of course occupy a central position, but the work from outside groups that you intend to publish will be a source of competitive stimulation for all of us."That first volume included 53 articles as well as critical reviews and book reviews. From that time on, the Annales appeared regularly every month, without interruption, even during the two world wars. Although the journal has undergone many changes over the past 100 years (in the title, the format, the language) reflecting the evolution in scientific publishing, it has consistently maintained the Pasteur tradition by publishing original reports on all aspects of microbiology.