[Biological essence of blood stasis-heat syndrome in ischemic stroke and current research status of traditional Chinese medicine prevention and treatment based on thromboinflammation reaction].

Q3 Pharmacology, Toxicology and Pharmaceutics
Jing Zhou, Zhi-Gang Mei
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引用次数: 0

Abstract

Blood stasis-heat syndrome is one of the common syndromes of ischemic stroke, which is manifested as syndromes of blood stasis and heat during the pathological progression of patients with ischemic stroke, but there is a lack of systematic research on its biological essence. Thromboinflammation reaction is a newly proposed pathological mechanism highly associated with thrombosis and inflammatory reaction, and it refers to the fact that under the mediation of von Willebrand factor(vWF) and the kallikrein-kinin system, thrombosis and inflammatory reaction interact with each other. Activation of T cells and neutrophils further aggravates thrombosis and worsens the pathological progression of ischemic stroke. Therefore, thromboinflammation reaction has the characteristics of the interaction between blood stasis and heat in blood stasis-heat syndrome in traditional Chinese medicine(TCM). Based on the research progress related to thromboinflammation reaction and the clinical syndrome characteristics and biomarkers of blood stasis-heat syndrome in ischemic stroke, this paper put forward the view that thromboinflammation reaction may be the biological foundation of blood stasis-heat syndrome in ischemic stroke. Besides, this paper systematically organized the current applications and research on the mechanism of TCM monomers or compound formulas with the effects of promoting blood circulation to remove blood stasis and clearing heat and detoxifying. It is found that the pharmacological mechanisms are intimately linked to the regulation of biomarkers related to thromboinflammation reaction, verifying that the biological foundation of the blood stasis-heat syndrome in ischemic stroke is thromboinflammation reaction. This paper aims to provide a scientific basis for TCM prevention and treatment strategies for ischemic stroke targeting thromboinflammation reaction.

[缺血性卒中血瘀热证的生物学本质及基于血栓炎症反应的中医防治研究现状]。
血瘀热证是缺血性脑卒中的常见证候之一,在缺血性脑卒中患者的病理进展中表现为血瘀热证候,但对其生物学本质缺乏系统的研究。血栓炎症反应是新近提出的一种与血栓形成和炎症反应高度相关的病理机制,是指在血管性血友病因子(vWF)和钾likrein-kinin系统的介导下,血栓形成和炎症反应相互作用。T细胞和中性粒细胞的活化进一步加重血栓形成,使缺血性卒中的病理进展恶化。因此,血栓炎症反应具有中医血瘀热证中血瘀热相互作用的特点。基于血栓炎症反应的相关研究进展,结合缺血性卒中血瘀热证的临床证候特征及生物标志物,本文提出血栓炎症反应可能是缺血性卒中血瘀热证的生物学基础。此外,本文还系统梳理了具有活血化瘀、清热解毒作用的中药单体或复方的应用及机理研究现状。发现其药理机制与血栓炎症反应相关的生物标志物调控密切相关,验证了缺血性卒中血瘀热证的生物学基础是血栓炎症反应。旨在为缺血性脑卒中血栓炎症反应的中医药防治策略提供科学依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Zhongguo Zhongyao Zazhi
Zhongguo Zhongyao Zazhi Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
1.50
自引率
0.00%
发文量
581
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