Multiple sclerosis and sickle cell anemia: when two worlds collide.

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY

Neurological Sciences Pub Date : 2025-04-01 Epub Date: 2025-01-14 DOI:10.1007/s10072-025-07997-z

Matteo Betti, Cristina Giubbilei, Simona D'angelo, Emilio Portaccio, Maria Pia Amato, Valentina Carrai

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引用次数: 0

Abstract

Background: The coexistence of sickle cell anemia and multiple sclerosis in a single patient presents a rare and challenging clinical scenario, possibly favoured by the interplay between chronic inflammatory states and autoimmune processes.

Methos/results: We present the case of a 36-year-old woman with sickle cell anemia who developed progressive neurological symptoms leading to frequent falls and paraparesis; magnetic resonance imaging showed many periventricular, infratentorial, and both cervical and dorsal spinal cord lesions, leading to a diagnosis of multiple sclerosis. After a multidisciplinary approach the patient was successfully started on ofatumumab.

Conclusion: This case report raises awareness among clinicians to consider the possibility of multiple sclerosis in patients with sickle cell anemia who present with neurological symptoms, ensuring timely diagnosis and intervention, and emphasizes the need for a personalized, multidisciplinary approach to care.

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多发性硬化症和镰状细胞性贫血：两个世界的碰撞。

背景：镰状细胞性贫血和多发性硬化症在单个患者中共存是一种罕见且具有挑战性的临床情况，可能是慢性炎症状态和自身免疫过程之间的相互作用所致。方法/结果：我们报告了一名患有镰状细胞性贫血的36岁女性，她出现了进行性神经系统症状，导致频繁跌倒和麻痹；磁共振成像显示许多脑室周围，幕下，以及颈椎和脊髓背侧病变，导致多发性硬化症的诊断。在多学科治疗后，患者成功开始使用ofatumumab。结论：本病例报告提高了临床医生对镰状细胞性贫血患者出现神经系统症状时多发性硬化可能性的认识，确保及时诊断和干预，并强调了个性化、多学科治疗方法的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurological Sciences 医学-临床神经学

CiteScore

6.10

自引率

3.00%

发文量

743

审稿时长

4 months

期刊介绍： Neurological Sciences is intended to provide a medium for the communication of results and ideas in the field of neuroscience. The journal welcomes contributions in both the basic and clinical aspects of the neurosciences. The official language of the journal is English. Reports are published in the form of original articles, short communications, editorials, reviews and letters to the editor. Original articles present the results of experimental or clinical studies in the neurosciences, while short communications are succinct reports permitting the rapid publication of novel results. Original contributions may be submitted for the special sections History of Neurology, Health Care and Neurological Digressions - a forum for cultural topics related to the neurosciences. The journal also publishes correspondence book reviews, meeting reports and announcements.