The telomere connection between aging and cancer: The burden of replication stress and dysfunction

IF 5.3 3区医学 Q2 CELL BIOLOGY

Mechanisms of Ageing and Development Pub Date : 2025-02-01 DOI:10.1016/j.mad.2025.112026

Virginia Boccardi , Luigi Marano

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引用次数: 0

Abstract

Aging is a complex process that affects individuals at the molecular, cellular, tissue, and systemic levels, arising from the cumulative effects of damage and reduced repair mechanisms. This process leads to the onset of age-related diseases, including cancer, which exhibits increased incidence with age. Telomeres, the protective caps at chromosome ends, play a crucial role in genome stability and are closely connected with aging and age-related disorders. Both excessively short and long telomere lengths may contribute to cancer development when their balance is disrupted. Fragile telomeres, characterized by abnormalities and replication stress, may provide novel insights into the connection between aging and cancer. The accumulation of fragile telomeres, possibly due to intense replicative stress, may represent a key factor. Given the dynamic nature of telomeres, large longitudinal studies are essential for understanding their role in aging and cancer susceptibility, which is crucial for developing effective strategies to promote healthy aging and mitigate cancer risk.

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衰老和癌症之间的端粒关系：复制压力和功能障碍的负担。

衰老是一个复杂的过程，它在分子、细胞、组织和系统水平上影响个体，是由损伤和修复机制减弱的累积效应引起的。这一过程导致与年龄有关的疾病，包括癌症的发病，其发病率随着年龄的增长而增加。端粒是染色体末端的保护帽，在基因组稳定中起着至关重要的作用，并与衰老和年龄相关疾病密切相关。当端粒长度的平衡被破坏时，过短和过长都可能导致癌症的发展。脆弱的端粒，以异常和复制压力为特征，可能为衰老和癌症之间的联系提供新的见解。脆弱端粒的积累，可能是由于强烈的复制压力，可能是一个关键因素。考虑到端粒的动态特性，大型纵向研究对于了解它们在衰老和癌症易感性中的作用至关重要，这对于制定促进健康衰老和降低癌症风险的有效策略至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mechanisms of Ageing and Development 医学-老年医学

CiteScore

11.10

自引率

1.90%

发文量

审稿时长

32 days

期刊介绍： Mechanisms of Ageing and Development is a multidisciplinary journal aimed at revealing the molecular, biochemical and biological mechanisms that underlie the processes of aging and development in various species as well as of age-associated diseases. Emphasis is placed on investigations that delineate the contribution of macromolecular damage and cytotoxicity, genetic programs, epigenetics and genetic instability, mitochondrial function, alterations of metabolism and innovative anti-aging approaches. For all of the mentioned studies it is necessary to address the underlying mechanisms. Mechanisms of Ageing and Development publishes original research, review and mini-review articles. The journal also publishes Special Issues that focus on emerging research areas. Special issues may include all types of articles following peered review. Proposals should be sent directly to the Editor-in-Chief.