Aura phenomenon: a proposal for an etiology-based clinical classification.

IF 7.3 1区医学 Q1 CLINICAL NEUROLOGY

Journal of Headache and Pain Pub Date : 2025-01-13 DOI:10.1186/s10194-024-01943-8

Umberto Pensato, Andrew M Demchuk, Jens P Dreier, Kevin C Brennan, Simona Sacco, Michele Romoli

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引用次数: 0

Abstract

Background: The term "aura" refers to a well-defined pattern of usually positive, progressive, and reversible neurological symptoms, with spreading depolarization as the underlying mechanism. While commonly associated with migraine, aura can also occur in other neurological disorders (i.e., cerebrovascular disorders). However, current terminology inadequately describes its different underlying clinical etiologies.

Main body: We propose the following terminology and etiology-based clinical classification for the aura phenomenon: (i) Migrainous Aura (when the etiology is migraine), (ii) Non-migrainous Aura (when there is an alternative etiology), (iii) Aura of uncertain clinical etiology (when etiology is unclear), and (iv) Migrainous Infarction (a typical migrainous aura in a patient with migraine with aura associated with an infarction in a corresponding anatomical brain region).

Conclusion: This nuanced classification aims to aid in the diagnostic evaluation and phenotyping of aura phenomenon, ultimately improving the diagnosis and management of the different associated neurological conditions. Moreover, it could promote effective communication and translational mechanistic research.

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先兆现象：一种基于病因的临床分类建议。

背景：术语“先兆”是指一种定义明确的模式，通常是阳性的、进行性的和可逆的神经症状，其潜在机制是扩散性去极化。虽然通常与偏头痛有关，但先兆也可能发生在其他神经系统疾病（即脑血管疾病）中。然而，目前的术语不足以描述其不同的潜在临床病因。正文：我们提出以下术语和基于病因的先兆现象临床分类：(i)偏头痛先兆（当病因为偏头痛时），（ii）非偏头痛先兆（当病因不明确时），（iii）临床病因不确定的先兆（当病因不明确时），以及（iv）偏头痛性梗死（偏头痛患者的典型偏头痛先兆，先兆与相应脑解剖区域的梗死相关）。结论：这种细致入微的分类旨在帮助先兆现象的诊断评估和表型，最终改善不同相关神经系统疾病的诊断和治疗。此外，它还可以促进有效的交流和翻译机制的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Headache and Pain 医学-临床神经学

CiteScore

11.80

自引率

13.50%

发文量

143

审稿时长

6-12 weeks

期刊介绍： The Journal of Headache and Pain, a peer-reviewed open-access journal published under the BMC brand, a part of Springer Nature, is dedicated to researchers engaged in all facets of headache and related pain syndromes. It encompasses epidemiology, public health, basic science, translational medicine, clinical trials, and real-world data. With a multidisciplinary approach, The Journal of Headache and Pain addresses headache medicine and related pain syndromes across all medical disciplines. It particularly encourages submissions in clinical, translational, and basic science fields, focusing on pain management, genetics, neurology, and internal medicine. The journal publishes research articles, reviews, letters to the Editor, as well as consensus articles and guidelines, aimed at promoting best practices in managing patients with headaches and related pain.