Serum FoxO1 and SIRT2 concentrations in healthy pregnant women and complicated by preeclampsia.

IF 1.7 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Asuman Akkaya Fırat, Ebru Alıcı Davutoğlu, Aysegül Özel, Serap Fırtına Tuncer, Nevin Yılmaz, Rıza Madazlı
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Abstract

Background: Sirtuins and FoxO1 are reported to be important in the pathophysiology of preeclampsia. This study aimed to investigate whether serum FoxO1 and SIRT2 concentrations differ between preeclampsia and normal pregnancy and also to compare these markers in early- and late-onset preeclampsia.

Methods: This cross-sectional study was conducted on 27 women with early-onset preeclampsia, 27 women with late-onset preeclampsia, and 26 healthy normotensive pregnant controls. Maternal serum levels of FoxO1 and SIRT2 were measured with the use of an enzyme-linked immunosorbent assay kit.

Results: The mean maternal serum FoxO1 levels were significantly lower both in early-onset (9.1 ± 3.8 vs. 29.1 ± 3.2, p < 0.001) and late-onset preeclampsia (2.6 ± 1.6 vs. 29.1 ± 3.2, p < 0.001) than the normotensive pregnancies. The mean maternal serum FoxO1 level of late-onset preeclampsia was significantly lower than the early-onset preeclampsia group (2.6 ± 1.6 vs. 9.1 ± 3.8, p < 0.001). The mean maternal serum SIRT2 levels were significantly lower both in early-onset (4.5 ± 2.1 vs. 6.3 ± 0.9, p < 0.001) and late-onset preeclampsia (2.1 ± 0.6 vs. 6.3 ± 0.9, p < 0.001) than the healthy pregnancies.

Conclusions: FoxO1 and SIRT2 may be biomarkers for early detection of preeclampsia and potential therapeutic targets in the pathophysiology of preeclampsia.

健康孕妇和子痫前期孕妇血清中 FoxO1 和 SIRT2 的浓度。
背景:Sirtuins和fox01在子痫前期的病理生理中起重要作用。本研究旨在探讨血清FoxO1和SIRT2浓度在子痫前期和正常妊娠之间是否存在差异,并比较这些标志物在早发性和晚发性子痫前期的差异。方法:对27例早发型子痫前期妇女、27例晚发型子痫前期妇女和26例血压正常的健康孕妇进行横断面研究。使用酶联免疫吸附测定试剂盒检测母体血清FoxO1和SIRT2水平。结论:FoxO1和SIRT2可能是早期发现子痫前期的生物标志物和子痫前期病理生理的潜在治疗靶点,FoxO1和SIRT2可能是早期发现子痫前期的生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Irish Journal of Medical Science
Irish Journal of Medical Science 医学-医学:内科
CiteScore
3.70
自引率
4.80%
发文量
357
审稿时长
4-8 weeks
期刊介绍: The Irish Journal of Medical Science is the official organ of the Royal Academy of Medicine in Ireland. Established in 1832, this quarterly journal is a contribution to medical science and an ideal forum for the younger medical/scientific professional to enter world literature and an ideal launching platform now, as in the past, for many a young research worker. The primary role of both the Academy and IJMS is that of providing a forum for the exchange of scientific information and to promote academic discussion, so essential to scientific progress.
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