Understanding the relationship between silicone implants, tumor antigens, and breast cancer risk: An immunological study in rats.

IF 4.8 2区医学 Q2 IMMUNOLOGY

International immunopharmacology Pub Date : 2025-02-06 Epub Date: 2025-01-12 DOI:10.1016/j.intimp.2024.113991

Yu Zhou, Zihao Li, Gaoyi Wang, Hua Yu, Yaqin Zhou, Yijun Li, Wanying Chen, Hao Dai, Yucang He, Liqun Li

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Abstract

This study aimed to investigate the effects of silicone implants on the incidence of breast cancer in rats, as well as their impact on immune surveillance mechanisms. Female SD rats were divided into three groups: a Placebo Surgery Group (PSG), a Thoracic Implant Group (TIG), and a Back Implant Group (BIG). Following the corresponding surgical procedures, we measured Secretoglobin Family 2A, Member 2(SCGB2A2) and Mucin-1 (MUC1) antigen levels using ELISA, and statistical analyses were conducted to evaluate immune responses. The N-Methyl-N-Nitrosourea(MNU)-induced breast cancer model and pathological analyses indicated that the incidence of breast cancer in the thoracic implant group was lower, suggesting that silicone implants may reduce the risk of breast cancer. Additionally, laser speckle blood flow imaging and immunohistochemical analysis revealed blood perfusion in the implant capsule area and an active response of immune cells, indicating that immune surveillance may exert local effects. These findings provide the first evidence of a relationship between tumor antigens, silicone implants, and breast cancer incidence, offering a new immunological perspective on the safety of silicone implants.

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了解硅胶植入物、肿瘤抗原和乳腺癌风险之间的关系：一项大鼠免疫学研究。

本研究旨在探讨硅胶植入物对大鼠乳腺癌发病率的影响及其对免疫监测机制的影响。雌性SD大鼠分为3组：安慰剂手术组（PSG）、胸部植入组（TIG）和背部植入组（BIG）。在相应的手术后，我们采用ELISA检测分泌珠蛋白家族2A、成员2（SCGB2A2）和Mucin-1 （MUC1）抗原水平，并进行统计分析以评价免疫应答。n -甲基- n -亚硝基脲（MNU）诱导的乳腺癌模型和病理分析显示，胸部植入组乳腺癌发病率较低，提示硅胶植入物可能降低乳腺癌风险。此外，激光散斑血流成像和免疫组织化学分析显示种植体包膜区血流灌注和免疫细胞的积极反应，表明免疫监测可能发挥局部作用。这些发现为肿瘤抗原、硅胶植入物和乳腺癌发病率之间的关系提供了第一个证据，为硅胶植入物的安全性提供了新的免疫学视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International immunopharmacology 医学-免疫学

CiteScore

8.40

自引率

3.60%

发文量

935

审稿时长

53 days

期刊介绍： International Immunopharmacology is the primary vehicle for the publication of original research papers pertinent to the overlapping areas of immunology, pharmacology, cytokine biology, immunotherapy, immunopathology and immunotoxicology. Review articles that encompass these subjects are also welcome. The subject material appropriate for submission includes: • Clinical studies employing immunotherapy of any type including the use of: bacterial and chemical agents; thymic hormones, interferon, lymphokines, etc., in transplantation and diseases such as cancer, immunodeficiency, chronic infection and allergic, inflammatory or autoimmune disorders. • Studies on the mechanisms of action of these agents for specific parameters of immune competence as well as the overall clinical state. • Pre-clinical animal studies and in vitro studies on mechanisms of action with immunopotentiators, immunomodulators, immunoadjuvants and other pharmacological agents active on cells participating in immune or allergic responses. • Pharmacological compounds, microbial products and toxicological agents that affect the lymphoid system, and their mechanisms of action. • Agents that activate genes or modify transcription and translation within the immune response. • Substances activated, generated, or released through immunologic or related pathways that are pharmacologically active. • Production, function and regulation of cytokines and their receptors. • Classical pharmacological studies on the effects of chemokines and bioactive factors released during immunological reactions.