Activation of Microglia and Astroglia in Unilateral Focal Traumatic Brain Injury in Rats.

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2024-12-01 Epub Date: 2025-01-07 DOI:10.1007/s10517-025-06306-0

E E Genrikhs, M O Shedenkova, D N Voronkov, N K Isaev, E V Stelmashook

引用次数: 0

Abstract

The number of microglia cells and astrocytes in layer V of the cerebral cortex was estimated on day 7 after damage caused by a unilateral focal traumatic brain injury of the left hemisphere sensorimotor cortex. Quantitative assessment was performed by counting immunocytochemically stained microglia cells (Iba1 marker) and activated astrocytes (GFAP) at different distances from the lesion site. Activation of microglial and astroglial cells was observed not only in the marginal zone of the lesion of the left hemisphere, but also in the intact hemisphere. The data obtained indicate the dissemination of inflammation in focal traumatic brain injury.

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单侧局灶性脑损伤大鼠小胶质细胞和星形胶质细胞的激活。

在左半球感觉运动皮层单侧局灶性脑损伤后第7天，测定大脑皮层V层小胶质细胞和星形胶质细胞的数量。定量评估通过计数免疫细胞化学染色的小胶质细胞（Iba1标记物）和活化的星形胶质细胞（GFAP）在不同距离的病变部位。小胶质细胞和星形胶质细胞不仅在左半球病变边缘区激活，而且在完整半球也有激活。所获得的数据表明局灶性创伤性脑损伤中炎症的播散。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.