Combined exposure to mixed brominated flame retardants on obstructive sleep apnea syndrome in US adults.

IF 3.5 2区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

BMC Public Health Pub Date : 2025-01-14 DOI:10.1186/s12889-024-21204-2

Junping Liu, Zhaoyue Liu, Xinru Liu, Nan Wang, Lin Wu, Xiaoxue Xu, Wei Liu, Yajie Feng, Huanyu Zhang, Yue Zhou, Xinle Yin, Yaping Liu, Qunhong Wu, Ning Ning, Libo Liang

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引用次数: 0

Abstract

Background: Accumulating research highlights that exposure to serum brominated flame retardants (BFRs) may elevate health risks. The effects of serum BFRs, both alone and in combination, on obstructive sleep apnea syndrome (OSAS) have not been thoroughly studied. Our main goal was to examine the association between individual and mixtures of serum BFRs and OSAS risk.

Methods: Data from the National Health and Nutrition Examination Survey (NHANES) were employed, including 1,341 participants. We included participants with full details on OSAS, covariates, and 7 types of serum BFRs (PBDE28, PBDE47, PBDE99, PBDE100, PBDE153, PBB153, and PBDE209). To investigate the OSAS risk with BFRs exposure, multivariate logistic regression, weighted quantile sum (WQS) regression, quantile g-computation (QGC), Bayesian kernel machine regression (BKMR) models, and restricted cubic splines (RCS) were implemented.

Results: Serum BFRs, including PBDE28, PBDE47, PBDE99, PBDE100, and PBB153, showed positive correlations with the OSAS risk. The toxic effect of serum BFRs co-exposure on OSAS risk was consistently demonstrated through the results of WQS regression, QGC and BKMR models. PBB153 was determined to be the most weighted BFRs. Additionally, RCS regression model also verified the strong non-linear relationship that existed between OSAS risk and PBB153.

Conclusions: Findings of the study prove that BFRs co-exposure exerts a deleterious effect on OSAS risk. Future large-scale prospective investigations and experimental studies are desirable to confirm these findings.

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来源期刊

BMC Public Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.50

自引率

4.40%

发文量

2108

审稿时长

1 months

期刊介绍： BMC Public Health is an open access, peer-reviewed journal that considers articles on the epidemiology of disease and the understanding of all aspects of public health. The journal has a special focus on the social determinants of health, the environmental, behavioral, and occupational correlates of health and disease, and the impact of health policies, practices and interventions on the community.