Combined exposure to mixed brominated flame retardants on obstructive sleep apnea syndrome in US adults.

IF 3.5 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Junping Liu, Zhaoyue Liu, Xinru Liu, Nan Wang, Lin Wu, Xiaoxue Xu, Wei Liu, Yajie Feng, Huanyu Zhang, Yue Zhou, Xinle Yin, Yaping Liu, Qunhong Wu, Ning Ning, Libo Liang
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引用次数: 0

Abstract

Background: Accumulating research highlights that exposure to serum brominated flame retardants (BFRs) may elevate health risks. The effects of serum BFRs, both alone and in combination, on obstructive sleep apnea syndrome (OSAS) have not been thoroughly studied. Our main goal was to examine the association between individual and mixtures of serum BFRs and OSAS risk.

Methods: Data from the National Health and Nutrition Examination Survey (NHANES) were employed, including 1,341 participants. We included participants with full details on OSAS, covariates, and 7 types of serum BFRs (PBDE28, PBDE47, PBDE99, PBDE100, PBDE153, PBB153, and PBDE209). To investigate the OSAS risk with BFRs exposure, multivariate logistic regression, weighted quantile sum (WQS) regression, quantile g-computation (QGC), Bayesian kernel machine regression (BKMR) models, and restricted cubic splines (RCS) were implemented.

Results: Serum BFRs, including PBDE28, PBDE47, PBDE99, PBDE100, and PBB153, showed positive correlations with the OSAS risk. The toxic effect of serum BFRs co-exposure on OSAS risk was consistently demonstrated through the results of WQS regression, QGC and BKMR models. PBB153 was determined to be the most weighted BFRs. Additionally, RCS regression model also verified the strong non-linear relationship that existed between OSAS risk and PBB153.

Conclusions: Findings of the study prove that BFRs co-exposure exerts a deleterious effect on OSAS risk. Future large-scale prospective investigations and experimental studies are desirable to confirm these findings.

混合溴化阻燃剂对美国成人阻塞性睡眠呼吸暂停综合征的影响
背景:越来越多的研究表明,暴露于血清溴化阻燃剂(BFRs)可能会增加健康风险。血清BFRs单独或联合对阻塞性睡眠呼吸暂停综合征(OSAS)的影响尚未得到充分研究。我们的主要目的是检查单个和混合血清BFRs与OSAS风险之间的关系。方法:采用全国健康与营养检查调查(NHANES)的数据,共1341名参与者。我们纳入了具有OSAS、协变量和7种血清BFRs (PBDE28、PBDE47、PBDE99、PBDE100、PBDE153、PBB153和PBDE209)详细信息的参与者。为了研究暴露于BFRs的OSAS风险,采用了多元逻辑回归、加权分位数和(WQS)回归、分位数g计算(QGC)、贝叶斯核机回归(BKMR)模型和限制三次样条(RCS)模型。结果:血清PBDE28、PBDE47、PBDE99、PBDE100、PBB153与OSAS风险呈正相关。通过WQS回归、QGC和BKMR模型的结果,一致证明了血清BFRs共暴露对OSAS风险的毒性作用。PBB153被确定为权重最大的BFRs。此外,RCS回归模型也验证了OSAS风险与PBB153之间存在较强的非线性关系。结论:本研究结果证明,BFRs共暴露会对OSAS风险产生有害影响。未来需要大规模的前瞻性调查和实验研究来证实这些发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMC Public Health
BMC Public Health 医学-公共卫生、环境卫生与职业卫生
CiteScore
6.50
自引率
4.40%
发文量
2108
审稿时长
1 months
期刊介绍: BMC Public Health is an open access, peer-reviewed journal that considers articles on the epidemiology of disease and the understanding of all aspects of public health. The journal has a special focus on the social determinants of health, the environmental, behavioral, and occupational correlates of health and disease, and the impact of health policies, practices and interventions on the community.
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