Reversing Cochlear Nucleus Maladaptive Plasticity via Customized Extracochlear Stimulation: A New Approach for Tinnitus Treatment

IF 14.3 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Min Chen, Shuwen Fan, Jiabao Mao, Linhan Huang, Nafisa Tursun, Chen Zhang, Wen Li, Shufeng Li
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Abstract

Tinnitus, a widespread condition affecting numerous individuals worldwide, remains a significant challenge due to limited effective therapeutic interventions. Intriguingly, patients using cochlear implants (CIs) have reported significant relief from tinnitus symptoms, although the underlying mechanisms remain unclear and intracochlear implantation risks cochlear damage and hearing loss. This study demonstrates that targeted intracochlear electrical stimulation (ES) in guinea pigs with noise-induced hearing loss reversed tinnitus-related maladaptive plasticity in the cochlear nucleus (CN), characterized by reduced auditory innervation, increased somatosensory innervation, and diminished inhibitory neural networks. Additionally, a customized extracochlear ES delivered by a newly designed extracochlear electrode array to guinea pigs with salicylate-induced tinnitus also reversed the aforementioned maladaptive plasticity and alleviated tinnitus without causing additional cochlear damage or hearing loss. These findings suggest that CI-delivered ES may alleviate tinnitus by reversing maladaptive CN plasticity. Additionally, the extracochlear ES strategy offers a promising tinnitus treatment with minimal risk to hearing.

Abstract Image

通过定制耳蜗外刺激逆转耳蜗核可塑性不良:耳鸣治疗的新途径。
耳鸣是一种影响全世界许多人的普遍疾病,由于有效的治疗干预措施有限,耳鸣仍然是一项重大挑战。有趣的是,使用人工耳蜗(CIs)的患者报告了耳鸣症状的显著缓解,尽管其潜在机制尚不清楚,并且人工耳蜗内植入有耳蜗损伤和听力损失的风险。本研究表明,噪声性听力损失豚鼠的针对性耳蜗内电刺激(ES)可逆转耳蜗核(CN)与耳鸣相关的适应性不良可塑性,其特征是听觉神经支配减少,体感神经支配增加,抑制性神经网络减少。此外,通过新设计的耳蜗外电极阵列将定制的耳蜗外ES传递给水杨酸诱发耳鸣的豚鼠,也逆转了上述适应性不良可塑性,减轻了耳鸣,而不会造成额外的耳蜗损伤或听力损失。这些研究结果表明,ci传递的ES可能通过逆转不适应的CN可塑性来缓解耳鸣。此外,耳蜗外ES策略提供了一种有前途的耳鸣治疗,对听力的风险最小。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Advanced Science
Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY
CiteScore
18.90
自引率
2.60%
发文量
1602
审稿时长
1.9 months
期刊介绍: Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.
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