Manganese carbonyl-encapsulated Fe-MOFs as a H2O2-responsive CO gas nanogenerator for synergistic gas/chemodynamic therapy†

IF 2.7 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

New Journal of Chemistry Pub Date : 2024-12-09 DOI:10.1039/D4NJ05085A

Fengqin Wang, Jian An, Shiyue Zhang, Jingjing Ma, Xufeng Liang, Jianxia Zhang, Jia Pu, Yujia Meng, Yiqiao Bai, Wenqiang Yu, Yunhan Gao, Yingfang Jiang, Tingting Chen, Yong Yao and Yang Wang

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Abstract

The combination of chemodynamic therapy (CDT) and gas therapy holds significant promise for tumor treatment. In this study, we successfully synthesized an intelligent H₂O₂-responsive Fe-MOF nanotherapeutic agent, integrated with glucose oxidase (GOx) and manganese carbonyl (MnCO), to achieve synergistic cancer gas/CDT. Upon endocytosis by tumor cells, the nanotherapeutic agent catalyzes the conversion of endogenous glucose into gluconic acid and H₂O₂, which facilitates the release of CO gas and disrupts the energy supply. Subsequently, a Fenton reaction occurs between Fe-MOFs and intracellular H₂O₂, generating highly toxic hydroxyl radicals (˙OH) for CDT. Therefore, the engineered nanotherapeutic agent demonstrates a synergistic efficacy through CO gas therapy, reactive oxygen species (ROS)-mediated CDT, and energy starvation, effectively suppressing tumor growth.

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