Hypocrellin A-mediated photodynamic antibacterial activity against Cutibacterium acnes: An in vitro study

IF 3.1 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-02-01 DOI:10.1016/j.pdpdt.2024.104467

Muqiu Zhang , Xinyao Liu , Xin Ran , Runyan Gao , Jitong Sun , Kaiwen Zhuang , Zimeng You , Zhi Zhang , Yuping Ran

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引用次数: 0

Abstract

Skin dysbiosis caused by Cutibacterium acnes contributes greatly to the complex pathogenesis of acne, and antimicrobial photodynamic therapy (PDT) has emerged as a promising treatment option for acne treatment. Hypocrellin, a photosensitizer extracted from a traditional Chinese medicinal fungus, has showed effective antimicrobial activity. This study aimed to evaluate the antibacterial ability of hypocrellin mediated PDT against Cutibacterium acnes. Using modified broth dilution method and morphological observation, the antibacterial effect was tested under a series of experimental conditions. The results showed that hypocrellin initiates type II photodynamic reactions by inducing amount of reactive oxygen species, particularly singlet oxygen. Within a certain concentration range, hypocrellin effectively maintained the antibacterial efficacy with minimal damage to keratinocyte cells. These results provide new insights into the use of PDT for acne treatment.

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Hypocrellin a介导的抗痤疮表皮杆菌光动力活性的体外研究

痤疮角质杆菌引起的皮肤生态失调是痤疮复杂发病机制的重要原因，抗菌光动力疗法已成为痤疮治疗的一种有前途的治疗选择。从中药真菌中提取的光敏剂金针菇素具有良好的抗菌活性。本研究旨在评价hypocrellin介导的PDT对痤疮表皮杆菌的抑菌能力。采用改良的肉汤稀释法和形态学观察，在一系列实验条件下对其抑菌效果进行了测试。结果表明，下花草素通过诱导活性氧，尤其是单线态氧的数量来引发II型光动力反应。在一定浓度范围内，hypocrellin能有效保持抗菌效果，且对角质形成细胞的损伤最小。这些结果为使用PDT治疗痤疮提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.