Rising cardiovascular mortality among obstructive sleep apnea patients: United States epidemiological trends (1999–2019)

IF 2.4 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Heart & Lung Pub Date : 2025-01-10 DOI:10.1016/j.hrtlng.2025.01.005

Dua Ali , Shaheer Qureshi , Hibah Siddiqui , Muhammad Salik Uddin , Saad Ahmed Waqas , Muhammad Khalid Afridi , Muhammad Umer Sohail , Sarah MacKenzie Picker , Farhan Shahid , Raheel Ahmed

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引用次数: 0

Abstract

Background

Obstructive sleep apnea (OSA) prevalence has risen significantly, affecting millions globally and posing a major healthcare burden. OSA is strongly associated with cardiovascular diseases (CVD) such as heart failure, stroke, and ischemic heart disease. However, trends in CVD-related mortality among individuals with OSA remain underexplored.

Objective

This study aims to assess the trends of OSA and CVD related mortality rates and variations in mortality based on demographics and regions in the US.

Methods

Mortality data for adults aged ≥25 with OSA and CVD were extracted from the CDC WONDER database. Age-adjusted mortality rates (AAMRs) per 100,000 and annual percent change (APC) with 95 % confidence intervals (CIs) were calculated, stratified by year, sex, race/ethnicity, age, urbanization, and Census regions.

Results

Between 1999 and 2019, 168,111 OSA-related CVD deaths were recorded. Overall AAMRs rose significantly, particularly for hypertensive disease (1999–2006 APC: 13.2 %, 95 % CI: 11.6–15.7). Men consistently had higher AAMRs than women, and Black individuals showed the highest racial disparities. AAMRs varied geographically, with the Midwest recording the highest rates and rural areas showing notable increases. States like Oregon and Montana had rates three times higher than New York and Massachusetts.

Conclusions

OSA-related CVD mortality has risen substantially, with marked disparities by sex, race, and region. These findings emphasize the need for targeted public health interventions to reduce mortality in high-risk groups.

Abstract Image

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阻塞性睡眠呼吸暂停患者心血管死亡率上升：美国流行病学趋势（1999-2019）。

背景：阻塞性睡眠呼吸暂停（OSA）的患病率显著上升，影响了全球数百万人，并造成了重大的医疗负担。OSA与心血管疾病（CVD）密切相关，如心力衰竭、中风和缺血性心脏病。然而，阻塞性睡眠呼吸暂停患者心血管疾病相关死亡率的趋势仍未得到充分研究。目的：本研究旨在评估美国OSA和CVD相关死亡率的趋势以及基于人口统计学和地区的死亡率变化。方法：从CDC WONDER数据库中提取年龄≥25岁的OSA合并CVD患者的死亡率数据。按年份、性别、种族/民族、年龄、城市化和人口普查地区进行分层，计算每10万人的年龄调整死亡率（AAMRs）和95%置信区间（CIs）的年变化率（APC）。结果：1999年至2019年期间，记录了168,111例osa相关的CVD死亡。总体aamr显著上升，特别是高血压疾病（1999-2006年APC: 13.2%, 95% CI: 11.6-15.7）。男性的aamr始终高于女性，黑人表现出最大的种族差异。aamr在地理上存在差异，中西部地区的发病率最高，农村地区的发病率显著上升。俄勒冈州和蒙大拿州等州的失业率是纽约州和马萨诸塞州的三倍。结论：osa相关CVD死亡率大幅上升，性别、种族和地区差异显著。这些发现强调有必要采取有针对性的公共卫生干预措施，以降低高危人群的死亡率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Heart & Lung 医学-呼吸系统

CiteScore

4.60

自引率

3.60%

发文量

184

审稿时长

35 days

期刊介绍： Heart & Lung: The Journal of Cardiopulmonary and Acute Care, the official publication of The American Association of Heart Failure Nurses, presents original, peer-reviewed articles on techniques, advances, investigations, and observations related to the care of patients with acute and critical illness and patients with chronic cardiac or pulmonary disorders. The Journal''s acute care articles focus on the care of hospitalized patients, including those in the critical and acute care settings. Because most patients who are hospitalized in acute and critical care settings have chronic conditions, we are also interested in the chronically critically ill, the care of patients with chronic cardiopulmonary disorders, their rehabilitation, and disease prevention. The Journal''s heart failure articles focus on all aspects of the care of patients with this condition. Manuscripts that are relevant to populations across the human lifespan are welcome.