Lignan Intake and Mortality Among Adults with Incident Type 2 Diabetes-Prospective Cohort Studies.

IF 6.5 1区医学 Q1 NUTRITION & DIETETICS

American Journal of Clinical Nutrition Pub Date : 2025-01-10 DOI:10.1016/j.ajcnut.2025.01.008

Binkai Liu, Yang Hu, Siyue Wang, Molin Wang, Eric B Rimm, Qi Sun

{"title":"Lignan Intake and Mortality Among Adults with Incident Type 2 Diabetes-Prospective Cohort Studies.","authors":"Binkai Liu, Yang Hu, Siyue Wang, Molin Wang, Eric B Rimm, Qi Sun","doi":"10.1016/j.ajcnut.2025.01.008","DOIUrl":null,"url":null,"abstract":"Background: Lignans are polyphenolic compounds abundant in plant-based foods such as seeds, whole grains, and certain fruits and vegetables and may lead to favorable metabolic health. It remains to be elucidated regarding the role of lignan consumption in the etiology of premature deaths among individuals with diabetes.Objectives: To prospectively examine the association between postdiagnosis lignan intake and mortality among individuals with type 2 diabetes (T2D).Methods: We analyzed data from 2 prospective United States cohorts, the Nurses' Health Study (1984-2020) and Health Professionals Follow-up Study (1986-2022). Mean daily consumption of total and individual lignans was calculated, and postdiagnosis lignan intakes were cumulatively averaged. Multivariable-adjusted Cox models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between lignan intake and mortality.Results: Among 8465 incident T2D cases contributing 116,026 person-years of follow-up, 4372 deaths were documented, including 1318 from cardiovascular disease (CVD) and 752 from cancer. The pooled multivariable-adjusted HRs (95% CIs) of all-cause mortality comparing the highest compared with the lowest quintiles of postdiagnosis lignan intake were 0.83 (0.74, 0.94) for total lignans, 0.89 (0.80, 0.99) for matairesinol (MAT), 0.78 (0.69, 0.87) for secoisolariciresinol (SECO), 0.91 (0.81, 1.01) for pinoresinol (PINO), and 0.92 (0.82, 1.03) for lariciresinol (LARIC). Higher postdiagnosis SECO intake was also significantly associated with lower CVD and cancer mortality. Changes in lignan intake from pre- to postdiagnosis showed similar favorable associations: 0.83 (0.75, 0.93) for total lignans, 0.86 (0.77, 0.96) for MAT, and 0.81 (0.72, 0.90) for SECO. The associations of lignan intake were significantly stronger among nonwhite individuals.Conclusions: Among individuals with T2D, a higher intake of lignans, particularly SECO, was significantly associated with reduced overall CVD and cancer mortality. Minority groups may particularly benefit from lignan intake, although further studies are warranted to substantiate this observation.","PeriodicalId":50813,"journal":{"name":"American Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":6.5000,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Clinical Nutrition","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ajcnut.2025.01.008","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Lignans are polyphenolic compounds abundant in plant-based foods such as seeds, whole grains, and certain fruits and vegetables and may lead to favorable metabolic health. It remains to be elucidated regarding the role of lignan consumption in the etiology of premature deaths among individuals with diabetes.

Objectives: To prospectively examine the association between postdiagnosis lignan intake and mortality among individuals with type 2 diabetes (T2D).

Methods: We analyzed data from 2 prospective United States cohorts, the Nurses' Health Study (1984-2020) and Health Professionals Follow-up Study (1986-2022). Mean daily consumption of total and individual lignans was calculated, and postdiagnosis lignan intakes were cumulatively averaged. Multivariable-adjusted Cox models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between lignan intake and mortality.

Results: Among 8465 incident T2D cases contributing 116,026 person-years of follow-up, 4372 deaths were documented, including 1318 from cardiovascular disease (CVD) and 752 from cancer. The pooled multivariable-adjusted HRs (95% CIs) of all-cause mortality comparing the highest compared with the lowest quintiles of postdiagnosis lignan intake were 0.83 (0.74, 0.94) for total lignans, 0.89 (0.80, 0.99) for matairesinol (MAT), 0.78 (0.69, 0.87) for secoisolariciresinol (SECO), 0.91 (0.81, 1.01) for pinoresinol (PINO), and 0.92 (0.82, 1.03) for lariciresinol (LARIC). Higher postdiagnosis SECO intake was also significantly associated with lower CVD and cancer mortality. Changes in lignan intake from pre- to postdiagnosis showed similar favorable associations: 0.83 (0.75, 0.93) for total lignans, 0.86 (0.77, 0.96) for MAT, and 0.81 (0.72, 0.90) for SECO. The associations of lignan intake were significantly stronger among nonwhite individuals.

Conclusions: Among individuals with T2D, a higher intake of lignans, particularly SECO, was significantly associated with reduced overall CVD and cancer mortality. Minority groups may particularly benefit from lignan intake, although further studies are warranted to substantiate this observation.

查看原文本刊更多论文

成年2型糖尿病患者木脂素摄入量和死亡率的前瞻性队列研究

背景：木脂素是一种多酚类化合物，富含植物性食物，如种子、全谷物和某些水果和蔬菜，可能导致有益的代谢健康。关于木脂素消费在糖尿病患者过早死亡的病因学中的作用仍有待阐明。目的：前瞻性研究诊断后木脂素摄入量与2型糖尿病（T2D）患者死亡率之间的关系。方法：我们分析了来自两个前瞻性美国队列的数据，护士健康研究（1984-2020）和卫生专业人员随访研究（1986-2022）。计算总木脂素和单个木脂素的平均每日消耗量，并计算诊断后木脂素摄入量的累积平均值。使用多变量校正Cox模型来估计木脂素摄入量与死亡率之间的风险比（hr）和95%置信区间（CIs）。结果：在8465例T2D病例中，随访116,026人年，记录了4372例死亡，其中1318例死于心血管疾病（CVD）， 752例死于癌症。诊断后木脂素摄入量最高和最低五分位数的全因死亡率的综合多变量调整hr （95% ci）为：总木脂素0.83(0.74,0.94)，松脂醇（MAT） 0.89(0.80, 0.99)，次异松脂醇（SECO） 0.78(0.69, 0.87)，松脂醇（PINO） 0.91(0.81, 1.01)，松脂醇（LARIC） 0.92（0.82, 1.03）。诊断后较高的SECO摄入量也与较低的心血管疾病和癌症死亡率显著相关。从诊断前到诊断后木脂素摄入量的变化显示出类似的有利关联：总木脂素为0.83 (0.75,0.93)，MAT为0.86 (0.77,0.96)，SECO为0.81（0.72,0.90）。木脂素摄入量的相关性在非白人个体中显著增强。结论：在T2D患者中，较高的木脂素摄入量，特别是SECO，与降低总体、心血管疾病和癌症死亡率显著相关。少数群体可能特别受益于木脂素的摄入，尽管需要进一步的研究来证实这一观察结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

American Journal of Clinical Nutrition 医学-营养学

CiteScore

12.40

自引率

4.20%

发文量

332

审稿时长

38 days

期刊介绍： American Journal of Clinical Nutrition is recognized as the most highly rated peer-reviewed, primary research journal in nutrition and dietetics.It focuses on publishing the latest research on various topics in nutrition, including but not limited to obesity, vitamins and minerals, nutrition and disease, and energy metabolism. Purpose: The purpose of AJCN is to: Publish original research studies relevant to human and clinical nutrition. Consider well-controlled clinical studies describing scientific mechanisms, efficacy, and safety of dietary interventions in the context of disease prevention or health benefits. Encourage public health and epidemiologic studies relevant to human nutrition. Promote innovative investigations of nutritional questions employing epigenetic, genomic, proteomic, and metabolomic approaches. Include solicited editorials, book reviews, solicited or unsolicited review articles, invited controversy position papers, and letters to the Editor related to prior AJCN articles. Peer Review Process: All submitted material with scientific content undergoes peer review by the Editors or their designees before acceptance for publication.