The association of the triglyceride-glucose index with the risk of atrial fibrillation: Analysis of the UK Biobank.

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2024-12-06 DOI:10.1016/j.numecd.2024.103826

Shanshan Shi, Yanjun Song, Zechen Liu, Jining He, Zhihao Zheng, Chenxi Song, Lei Jia, Guofeng Gao, Qiuting Dong, Rui Fu, Min Yang, Wenjia Zhang, Kefei Dou

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引用次数: 0

Abstract

Background and aims: The relationship between the triglyceride-glucose (TyG) index and the incidence of atrial fibrillation (AF) remains insufficiently explored. This investigation aims to elucidate the association between the TyG index and the long-term risk of developing AF.

Methods and results: This cohort study analyzed data from 409,705 participants sourced from the UK Biobank database. Participants were stratified into three groups based on TyG index tertiles. The association between the TyG index and AF was evaluated using Cox proportional hazards models. Restricted cubic spline (RCS) analysis was employed to investigate potential linear or nonlinear relationships. During a mean follow-up period of 13.9 years, 26,092 AF cases were recorded. Compared with the T2 group, participants in the T1 group and T3 group presented a significantly higher risk of AF (T1: HR: 1.22, 95%CI: 1.17-1.27; T3: HR: 1.09, 95%CI: 1.05-1.14). RCS analysis documented a U-shaped relationship between the TyG index and the risk of AF (P for non-linearity <0.001). In non-type 2 diabetes (T2D) participants, TyG levels were associated with AF risk in a U-shaped relationship. Among T2D participants, only the T3 group had an increased risk of AF (reverse "L" pattern). The U-shaped relationship between TyG levels and AF risk remained consistent across heart valve disease (HVD) and non-HVD patients, as well as different strata of genetic susceptibility to AF.

Conclusions: This study demonstrates a U-shaped association between the TyG index and the risks of AF, underscoring the index's potential utility in identifying individuals at elevated risk for these conditions.

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甘油三酯-葡萄糖指数与房颤风险的关系：英国生物银行的分析。

背景与目的：甘油三酯-葡萄糖（TyG）指数与心房颤动（AF）发病率之间的关系尚未得到充分探讨。本研究旨在阐明TyG指数与发生af的长期风险之间的关系。方法和结果：本队列研究分析了来自英国生物银行数据库的409,705名参与者的数据。根据TyG指数将参与者分为三组。使用Cox比例风险模型评估TyG指数与AF之间的相关性。限制三次样条（RCS）分析用于研究潜在的线性或非线性关系。在平均13.9年的随访期间，记录了26,092例房颤病例。与T2组相比，T1组和T3组发生AF的风险显著升高(T1: HR: 1.22, 95%CI: 1.17-1.27；T3: hr: 1.09, 95%ci: 1.05-1.14)。RCS分析记录了TyG指数与房颤风险之间的u型关系（P为非线性）。结论：本研究证明了TyG指数与房颤风险之间的u型关系，强调了该指数在识别这些疾病高风险个体方面的潜在效用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition Metabolism and Cardiovascular Diseases 医学-内分泌学与代谢

CiteScore

6.80

自引率

2.60%

发文量

332

审稿时长

57 days

期刊介绍： Nutrition, Metabolism & Cardiovascular Diseases is a forum designed to focus on the powerful interplay between nutritional and metabolic alterations, and cardiovascular disorders. It aims to be a highly qualified tool to help refine strategies against the nutrition-related epidemics of metabolic and cardiovascular diseases. By presenting original clinical and experimental findings, it introduces readers and authors into a rapidly developing area of clinical and preventive medicine, including also vascular biology. Of particular concern are the origins, the mechanisms and the means to prevent and control diabetes, atherosclerosis, hypertension, and other nutrition-related diseases.