The relationship between nonalcoholic fatty liver disease and frailty: A systematic review and meta-analysis

IF 4.3 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2025-02-01 DOI:10.1016/j.dsx.2025.103187

Shaghayegh Khanmohammadi , Mahdi Masrour , Parisa Fallahtafti , Amirhossein Habibzadeh , Art Schuermans , Mohammad Shafi Kuchay

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引用次数: 0

Abstract

Background and aim

Frailty is frequently observed in end-stage liver disease of various etiologies, but its role in nonalcoholic fatty liver disease (NAFLD) remains incompletely understood. We aimed to conduct a systematic review and meta-analysis to assess the association and prevalence of frailty in NAFLD.

Methods

A systematic review of PubMed/MEDLINE, EMBASE, Web of Science, and Scopus was performed. The random-effects model was used to estimate the pooled prevalence of frailty. Meta-analyzed odds ratios (OR) were calculated to examine the association between frailty and NAFLD.

Results

Among the initial 430 articles identified, 18 studies were included. Three studies involving 3673 participants had a pooled OR of 2.03 (95% CI: 1.51–2.72; I^2 = 1.1%; p < 0.0001) for the association between frailty and NAFLD. The pooled prevalence of frailty in individuals with NAFLD was 23% (95% CI: 13%–38%; I^2 = 93.5%) using the liver frailty index (LFI) and 8% (95% CI: 3%–21%; I^2 = 98.1%) using the Fried frailty index (FFI). NAFLD patients’ mean grip strength and balance time were 26.4 kg (95% CI: 23.0–29.8) and 23s (95% CI: 10–35), respectively. Among studies that also included individuals with liver cirrhosis, grip strength was lower in those with cirrhosis vs. the broader population of those with NAFLD.

Conclusions

Our study suggests that frailty is highly prevalent in individuals with NAFLD, with a significantly higher prevalence compared to those without NAFLD. Individuals with NAFLD have more than two-fold increased odds of frailty. Assessing frailty in NAFLD patients enables targeted management to improve outcomes.

查看原文本刊更多论文

非酒精性脂肪肝与虚弱之间的关系：系统回顾和荟萃分析。

背景和目的：虚弱在各种病因的终末期肝病中经常观察到，但其在非酒精性脂肪性肝病（NAFLD）中的作用仍不完全清楚。我们的目的是进行一项系统回顾和荟萃分析，以评估NAFLD中虚弱的相关性和患病率。方法：系统回顾PubMed/MEDLINE、EMBASE、Web of Science和Scopus数据库。随机效应模型用于估计虚弱的总患病率。计算meta分析的优势比（OR）来检验虚弱和NAFLD之间的关系。结果：在最初确定的430篇文章中，纳入了18项研究。三项研究共涉及3673名受试者，合并OR为2.03 (95% CI: 1.51-2.72；i ^2 = 1.1%；结论：我们的研究表明，虚弱在NAFLD患者中非常普遍，其患病率明显高于非NAFLD患者。患有NAFLD的人身体虚弱的几率增加了两倍多。评估NAFLD患者的虚弱可以使有针对性的管理改善预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes & Metabolic Syndrome-Clinical Research & Reviews ENDOCRINOLOGY & METABOLISM-

CiteScore

22.90

自引率

2.00%

发文量

248

审稿时长

51 days

期刊介绍： Diabetes and Metabolic Syndrome: Clinical Research and Reviews is the official journal of DiabetesIndia. It aims to provide a global platform for healthcare professionals, diabetes educators, and other stakeholders to submit their research on diabetes care. Types of Publications: Diabetes and Metabolic Syndrome: Clinical Research and Reviews publishes peer-reviewed original articles, reviews, short communications, case reports, letters to the Editor, and expert comments. Reviews and mini-reviews are particularly welcomed for areas within endocrinology undergoing rapid changes.