Factors associated with clinical alterations in patients diagnosed with HIV

IF 3.7 3区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Research in Social & Administrative Pharmacy Pub Date : 2025-01-07 DOI:10.1016/j.sapharm.2025.01.003

Jorge Iván Estrada-Acevedo, Alejandra Rendón-Montoya, Juliana Madrigal-Cadavid, Marisella Londoño, Maria Jackeline Galvis

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Abstract

Background

In recent years, the life expectancy of HIV patients has increased due to the introduction and development of antiretroviral therapies. However, although it has become a chronic pathology, the patients present a higher metabolic, hepatic, and renal risk and a greater aging than the general population.

Objective

To identify the main factors associated with clinical alterations in patients with HIV.

Methods

Observational, descriptive, retrospective, retrospective study in HIV patients attended by a pharmaceutical manager during 2023. A descriptive analysis was performed with measures of central tendency and summary, and a bivariate and multivariate analysis by means of logistic regression considering the presence of clinical alterations as the dependent variable.

Results

A total of 11126 HIV-positive patients were evaluated, mainly men (90 %), with a mean age of 40 years (SD 12.8) and a range between 19 and 95 years. A total of 48.5 % presented clinical alterations at risk levels that should be intervened in a timely manner to ensure the patient's adequate health status. Factors such as age, antiretroviral regimen, adherence, and drug persistence (p < 0.001) were found to be associated with the development of clinical alterations in patients with HIV.

Conclusions

Establishing a prioritization in the follow-up and management of HIV patients focused on patients older than 60 years, with treatment regimens that include protease inhibitors and non-nucleoside reverse transcriptase inhibitors, in antiretroviral therapy initiation, non-adherent and/or with drug persistence problems, could generate more effective interventions focused on reducing clinical risks.

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与HIV患者临床改变相关的因素

背景：近年来，由于抗逆转录病毒疗法的引入和发展，艾滋病毒患者的预期寿命有所增加。然而，尽管它已成为一种慢性病理，但与一般人群相比，患者表现出更高的代谢、肝脏和肾脏风险和更大的衰老。目的：探讨与HIV患者临床改变相关的主要因素。方法：采用观察性、描述性、回顾性、回顾性研究方法，对2023年由一名药品管理人员就诊的HIV患者进行调查。描述性分析采用集中趋势和总结的方法进行，并采用考虑临床改变作为因变量的逻辑回归方法进行双变量和多变量分析。结果：共评估了11126例hiv阳性患者，以男性为主（90%），平均年龄40岁（SD 12.8），年龄在19 ~ 95岁之间。共有48.5%的患者表现出临床改变，处于危险水平，应及时干预，以确保患者的适当健康状况。结论：针对年龄大于60岁、治疗方案包括蛋白酶抑制剂和非核苷类逆转录酶抑制剂的HIV患者，在抗逆转录病毒治疗开始、不坚持和/或有药物持续性问题的患者，建立随访和管理的优先顺序，可以产生更有效的干预措施，重点是降低临床风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Research in Social & Administrative Pharmacy PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

7.20

自引率

10.30%

发文量

225

审稿时长

47 days

期刊介绍： Research in Social and Administrative Pharmacy (RSAP) is a quarterly publication featuring original scientific reports and comprehensive review articles in the social and administrative pharmaceutical sciences. Topics of interest include outcomes evaluation of products, programs, or services; pharmacoepidemiology; medication adherence; direct-to-consumer advertising of prescription medications; disease state management; health systems reform; drug marketing; medication distribution systems such as e-prescribing; web-based pharmaceutical/medical services; drug commerce and re-importation; and health professions workforce issues.