Comparison of a Novel Ultra-Widefield Three-Color Scanning Laser Ophthalmoscope to Other Retinal Imaging Modalities in Chorioretinal Lesion Imaging.

IF 2.6 3区医学 Q2 OPHTHALMOLOGY

Translational Vision Science & Technology Pub Date : 2025-01-02 DOI:10.1167/tvst.14.1.11

Ines D Nagel, Anna Heinke, Akshay P Agnihotri, Shaden Yassin, Lingyun Cheng, Andrew S Camp, Nathan L Scott, Fritz Gerald P Kalaw, Shyamanga Borooah, Dirk-Uwe G Bartsch, Arthur J Mueller, Nehal Mehta, William R Freeman

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Abstract

Purpose: To compare the assessment of clinically relevant retinal and choroidal lesions as well as optic nerve pathologies using a novel three-wavelength ultra-widefield (UWF) scanning laser ophthalmoscope with established retinal imaging techniques for ophthalmoscopic imaging.

Methods: Eighty eyes with a variety of retinal and choroidal lesions were assessed on the same time point using Topcon color fundus photography (CFP) montage, Optos red/green (RG), Heidelberg SPECTRALIS MultiColor 55-color montage (MCI), and novel Optos red/green/blue (RGB). Paired images of the optic nerve, retinal, or choroidal lesions were initially diagnosed based on CFP imaging. The accuracy of the imaging was then evaluated in comparison to CFP using a grading scale ranging from -1 (losing imaging information) to +1 (gaining imaging information).

Results: Eighty eyes of 43 patients with 116 retinal or choroidal pathologies, as well as 59 eyes with optic nerve imaging using CFP, MCI, RG, and RGB, were included in this study. Across all subgroups, RGB provided significantly more accurate clinical imaging with CFP as ground truth and compared to other modalities. This was true comparing RGB to both RG (P = 0.0225) and MCI (P < 0.001) overall. Although RGB provided more accurate clinical information overall, it was inferior to RG for melanocytic choroidal lesions (P = 0.011).

Conclusions: RGB can be considered as a useful tool to detect characteristics of central, midperipheral, and peripheral retinal lesions. Regarding melanocytic choroidal lesions, RGB was inferior to RG, and MCI was inferior to both RG and RGB modalities due to color changes.

Translational relevance: Traditional retinal ultra-widefield imaging uses two wavelengths. Here, we evaluated three wavelengths for ultra-widefield imaging. We examined new optics (basic science) effect on patient imaging (clinical care).

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一种新型超宽视场三色扫描激光检眼镜与其他视网膜成像方式在绒毛膜视网膜病变成像中的比较。

目的：比较新型三波长超宽视场（UWF）扫描激光检眼镜与已有的视网膜成像技术对临床相关视网膜、脉络膜病变及视神经病变的评估。方法：采用Topcon彩色眼底摄影（CFP）蒙太奇、Optos红/绿（RG）、Heidelberg SPECTRALIS多色55色蒙太奇（MCI）和新颖的Optos红/绿/蓝（RGB），在同一时间点对80只不同视网膜和巩膜病变的眼进行评估。配对图像的视神经，视网膜，或脉络膜病变最初诊断基于CFP成像。然后使用从-1（失去成像信息）到+1（获得成像信息）的分级量表与CFP进行比较，评估成像的准确性。结果：本研究纳入43例视网膜或脉络膜病变患者80只眼，116例视网膜或脉络膜病变，59例视神经影像学采用CFP、MCI、RG、RGB。在所有亚组中，与其他方式相比，RGB提供了以CFP为基础的更准确的临床成像。总的来说，RGB与RG （P = 0.0225）和MCI （P < 0.001）相比是正确的。虽然RGB总体上提供了更准确的临床信息，但对于黑素细胞性脉络膜病变，RGB不如RG （P = 0.011）。结论：RGB可作为检测视网膜中央、中外周和外周病变特征的有效工具。对于黑素细胞性脉络膜病变，由于颜色的改变，RGB模式不如RG模式，MCI模式不如RG模式和RGB模式。翻译相关性：传统的视网膜超宽视场成像使用两个波长。在这里，我们评估了超宽视场成像的三个波长。我们考察了新光学（基础科学）对患者成像（临床护理）的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Translational Vision Science & Technology Engineering-Biomedical Engineering

CiteScore

5.70

自引率

3.30%

发文量

346

审稿时长

25 weeks

期刊介绍： Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO. The journal covers a broad spectrum of work, including but not limited to: Applications of stem cell technology for regenerative medicine, Development of new animal models of human diseases, Tissue bioengineering, Chemical engineering to improve virus-based gene delivery, Nanotechnology for drug delivery, Design and synthesis of artificial extracellular matrices, Development of a true microsurgical operating environment, Refining data analysis algorithms to improve in vivo imaging technology, Results of Phase 1 clinical trials, Reverse translational ("bedside to bench") research. TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.