Impact of Reduction of 2% Topical Ganciclovir on Recurrence of Cytomegalovirus Iritis.

IF 2.6 4区医学 Q2 OPHTHALMOLOGY

Ocular Immunology and Inflammation Pub Date : 2025-01-13 DOI:10.1080/09273948.2024.2446417

Yuta Nariya, Takashi Ono, Takahiro Minami, Makoto Aihara, Rie Tanaka, Takashi Miyai

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Abstract

Purpose: To examine the recurrence of cytomegalovirus (CMV) iritis in patients using low-dose ganciclovir (GCV) eye drops.

Methods: We included patients with dormant CMV iritis who were treated using 2% GCV eye drops at the University of Tokyo Hospital between January and June 2023 and whose dosage of GCV eye drops was required to be reduced due to the unstable GCV supply. Patients were excluded if they had active CMV retinitis and underwent corneal transplantation. We examined the recurrence of CMV iritis after the reduction of GCV eye drops.

Results: Fifteen eyes of 14 patients (mean age, 62.4 ± 13.0 years) were included. The frequency of GCV eye drops was reduced from four times a day to twice in 13 eyes and three times in two eyes. The mean observation period after the reduction of GCV eye drops was 202.5 ± 155.8 days. Although there were no recurrences in the 6 months prior to the reduction of GCV eye drops, recurrences were observed in five eyes (33.3%) after the reduction. The mean time from GCV reduction to recurrence was 59.2 ± 11.3 days. Patients who survived the first 3 months without recurrence had no recurrence later.

Conclusion: Recurrences of CMV iritis were observed in one-third of the eyes within 3 months after dosage reduction of 2% GCV eye drops.

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局部减少2%更昔洛韦对巨细胞病毒虹膜炎复发的影响。

目的：探讨使用低剂量更昔洛韦（GCV）滴眼液的患者巨细胞病毒（CMV）虹膜炎的复发率。方法：我们纳入了2023年1月至6月在东京大学医院使用2% GCV滴眼液治疗的休眠CMV虹膜炎患者，由于GCV供应不稳定，需要减少GCV滴眼液的剂量。如果患者患有活动性巨细胞病毒性视网膜炎并进行了角膜移植，则排除。我们检查了减少GCV滴眼液后巨细胞病毒性虹膜炎的复发情况。结果：纳入14例患者15只眼，平均年龄62.4±13.0岁。GCV滴眼液的频率从每天4次减少到13只眼睛的2次和2只眼睛的3次。GCV滴眼液减少后的平均观察时间为202.5±155.8 d。虽然在减少GCV滴眼液前6个月内没有复发，但减少GCV滴眼液后有5只眼（33.3%）复发。从GCV减少到复发的平均时间为59.2±11.3天。存活3个月无复发的患者以后无复发。结论：减少2% GCV滴眼液剂量后3个月内，三分之一的眼睛出现巨细胞病毒性虹膜炎复发。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ocular Immunology and Inflammation 医学-眼科学

CiteScore

6.20

自引率

15.20%

发文量

285

审稿时长

6-12 weeks

期刊介绍： Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.