{"title":"Hypercalcaemia in association with Sertoli cell tumour in a dog.","authors":"K Strait, M A Mickelson, I Hildebrandt, O Skinner","doi":"10.1111/jsap.13820","DOIUrl":null,"url":null,"abstract":"<p><p>A 9-year-old, presumed male castrated mixed breed dog was evaluated for lethargy, hyporexia, polyuria, polydipsia and diffuse gynaecomastia. Bloodwork revealed severe hypercalcaemia and hyposthenuria. CT scan showed a caudal abdominal mass consistent with a Sertoli cell tumour on cytology. Diffuse, nodular mammary gland enlargement was consistent with mammary gland hyperplasia on cytology. A malignancy panel was inconsistent with hyperparathyroidism and showed a normal PTHrP. Abdominal exploratory laparotomy, abdominal mass resections and right chain mammectomy were performed. Sertoli cell tumour and mammary gland hyperplasia were confirmed via histopathology. Hypercalcaemia decreased to within normal range and gynaecomastia in the left mammary chain resolved postoperatively. To the authors' knowledge, this is the first case report of hypercalcaemia associated with Sertoli cell tumour in a dog. While several mechanisms have been proposed for hypercalcaemia of malignancy, the mechanism is unclear in this case.</p>","PeriodicalId":17062,"journal":{"name":"Journal of Small Animal Practice","volume":" ","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Small Animal Practice","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1111/jsap.13820","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
A 9-year-old, presumed male castrated mixed breed dog was evaluated for lethargy, hyporexia, polyuria, polydipsia and diffuse gynaecomastia. Bloodwork revealed severe hypercalcaemia and hyposthenuria. CT scan showed a caudal abdominal mass consistent with a Sertoli cell tumour on cytology. Diffuse, nodular mammary gland enlargement was consistent with mammary gland hyperplasia on cytology. A malignancy panel was inconsistent with hyperparathyroidism and showed a normal PTHrP. Abdominal exploratory laparotomy, abdominal mass resections and right chain mammectomy were performed. Sertoli cell tumour and mammary gland hyperplasia were confirmed via histopathology. Hypercalcaemia decreased to within normal range and gynaecomastia in the left mammary chain resolved postoperatively. To the authors' knowledge, this is the first case report of hypercalcaemia associated with Sertoli cell tumour in a dog. While several mechanisms have been proposed for hypercalcaemia of malignancy, the mechanism is unclear in this case.
期刊介绍：
Journal of Small Animal Practice (JSAP) is a monthly peer-reviewed publication integrating clinical research papers and case reports from international sources, covering all aspects of medicine and surgery relating to dogs, cats and other small animals. These papers facilitate the dissemination and implementation of new ideas and techniques relating to clinical veterinary practice, with the ultimate aim of promoting best practice. JSAP publishes high quality original articles, as well as other scientific and educational information. New developments are placed in perspective, encompassing new concepts and peer commentary. The target audience is veterinarians primarily engaged in the practise of small animal medicine and surgery.
In addition to original articles, JSAP will publish invited editorials (relating to a manuscript in the same issue or a topic of current interest), review articles, which provide in-depth discussion of important clinical issues, and other scientific and educational information from around the world.
The final decision on publication of a manuscript rests with the Editorial Board and ultimately with the Editor. All papers, regardless of type, represent the opinion of the authors and not necessarily that of the Editor, the Association or the Publisher.
The Journal of Small Animal Practice is published on behalf of the British Small Animal Veterinary Association and is also the official scientific journal of the World Small Animal Veterinary Association
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