Mechanism of adolescent depression and Non-Suicidal Self-Injury: Interaction between interpersonal relationship and the OXTR gene

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research Pub Date : 2025-02-01 DOI:10.1016/j.jpsychires.2024.12.031

Zihao Zeng , Shan Ding , Shuangjin Liu , Hongcai Wang , Qin Yang , Yiqiu Hu , Yong Liu

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引用次数: 0

Abstract

Background

Based on ecosystem theory and genetic and environmental research paradigms, the current research explored the influence mechanism of interpersonal relationship and OXTR gene rs1042778, rs2254298 and rs53576 polymorphisms on adolescent depression and NSSI.

Method

The main study investigation explored the effect of the interaction between interpersonal relationship and OXTR gene on adolescent depression and Non-Suicidal Self-Injury (NSSI). Concurrently, a supplementary examination investigated oxytocin's physiological impact on the social-emotional behaviors of mice subjected to post-weaning social isolation.

Results

OXTR gene rs2254298 and rs53576 moderated the influence of interpersonal relationship on adolescent depression, and rs2254298 also moderated the influence of interpersonal relationship on adolescent NSSI. PWSI reduced the mice's emotional social ability and affected the expression and transcription of OXT and OXTR mRNA, which could be reversed after an appropriate dose of oxytocin treatment.

Conclusion

Interaction between interpersonal relationship and the OXTR gene affects adolescent depression and NSSI. The OXTR gene heterozygous genotype individuals were more sensitive to environmental stimuli, supporting the differential susceptibility model.

查看原文本刊更多论文

青少年抑郁与非自杀性自伤的机制：人际关系与OXTR基因的相互作用。

背景：本研究基于生态系统理论和遗传环境研究范式，探讨人际关系和OXTR基因rs1042778、rs2254298和rss53576多态性对青少年抑郁和自伤的影响机制。方法：主要研究人际关系与OXTR基因的交互作用对青少年抑郁和非自杀性自伤（NSSI）的影响。同时，一项补充研究调查了催产素对断奶后社会隔离小鼠社会情绪行为的生理影响。结果：OXTR基因rs2254298和rss53576调节了人际关系对青少年抑郁的影响，rs2254298也调节了人际关系对青少年自伤的影响。PWSI降低了小鼠的情感社交能力，影响了OXT和OXTR mRNA的表达和转录，在适当剂量的催产素处理后，这种情况可以逆转。结论：人际关系与OXTR基因的相互作用影响青少年抑郁和自伤。OXTR基因杂合型个体对环境刺激更敏感，支持差异易感性模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of psychiatric research 医学-精神病学

CiteScore

7.30

自引率

2.10%

发文量

622

审稿时长

130 days

期刊介绍： Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;