Associations of phenols, parabens, and phthalates with biological aging: stratified analyses by chronological age and lifestyle in NHANES 2005-2010.

IF 2.2 4区医学 Q3 ENVIRONMENTAL SCIENCES

International Journal of Environmental Health Research Pub Date : 2025-01-12 DOI:10.1080/09603123.2025.2451626

Han Ma, Jinyue Li, Hanping Ma

{"title":"Associations of phenols, parabens, and phthalates with biological aging: stratified analyses by chronological age and lifestyle in NHANES 2005-2010.","authors":"Han Ma, Jinyue Li, Hanping Ma","doi":"10.1080/09603123.2025.2451626","DOIUrl":null,"url":null,"abstract":"Humans are widely exposed to phenols, parabens, and phthalates with health risks, while the effects of these chemicals on biological aging remain unclear. Among 3,441 adults in the National Health and Nutrition Examination Survey 2005-2010, phenol, paraben, and phthalate concentrations were measured and phenotypic age acceleration (PhenoAgeAccel) was calculated. Linear regression and weighted quantile sum (WQS) regression were used to evaluate the associations of single and mixed chemicals with PhenoAgeAccel. Stratified analyses by chronological age and lifestyle were also performed. Individual phthalates were positively associated with PhenoAgeAccel. The WQS model found the positive relationship between mixed chemicals with PhenoAgeAccel (β = 0.175, 95%CI: 0.001, 0.349). The adverse impacts of phenols and phthalates on biological aging were stronger in older participants with significant interactions. Adherence to healthier lifestyle might partly reduce the positive relationships of phenols and phthalates with biological aging, especially among older adults, which is expected to be a viable intervention in the future.","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-17"},"PeriodicalIF":2.2000,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Environmental Health Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/09603123.2025.2451626","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Humans are widely exposed to phenols, parabens, and phthalates with health risks, while the effects of these chemicals on biological aging remain unclear. Among 3,441 adults in the National Health and Nutrition Examination Survey 2005-2010, phenol, paraben, and phthalate concentrations were measured and phenotypic age acceleration (PhenoAgeAccel) was calculated. Linear regression and weighted quantile sum (WQS) regression were used to evaluate the associations of single and mixed chemicals with PhenoAgeAccel. Stratified analyses by chronological age and lifestyle were also performed. Individual phthalates were positively associated with PhenoAgeAccel. The WQS model found the positive relationship between mixed chemicals with PhenoAgeAccel (β = 0.175, 95%CI: 0.001, 0.349). The adverse impacts of phenols and phthalates on biological aging were stronger in older participants with significant interactions. Adherence to healthier lifestyle might partly reduce the positive relationships of phenols and phthalates with biological aging, especially among older adults, which is expected to be a viable intervention in the future.

查看原文本刊更多论文

苯酚、对羟基苯甲酸酯和邻苯二甲酸酯与生物衰老的关系：2005-2010 年 NHANES 中按实际年龄和生活方式进行的分层分析。

人类广泛接触有健康风险的酚类、对羟基苯甲酸酯和邻苯二甲酸酯，而这些化学物质对生物衰老的影响尚不清楚。在2005-2010年全国健康与营养检查调查中，对3,441名成年人进行了苯酚、对羟基苯甲酸酯和邻苯二甲酸盐浓度的测量，并计算了表型年龄加速（PhenoAgeAccel）。采用线性回归和加权分位数和（WQS）回归来评估单一和混合化学品与PhenoAgeAccel的关系。按实际年龄和生活方式进行分层分析。单个邻苯二甲酸酯与PhenoAgeAccel呈正相关。WQS模型发现混合化学品与PhenoAgeAccel呈正相关（β = 0.175, 95%CI: 0.001, 0.349）。酚类和邻苯二甲酸酯对老年参与者的生物衰老的不利影响更大，具有显著的相互作用。坚持更健康的生活方式可能会在一定程度上减少酚类和邻苯二甲酸酯与生物衰老的积极关系，特别是在老年人中，这有望成为未来可行的干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Environmental Health Research 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.70

自引率

3.10%

发文量

134

审稿时长

>12 weeks

期刊介绍： International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.