Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) from contaminated water and risk of childhood cancer in California, 2000-2015.

IF 3.3 Q2 ENVIRONMENTAL SCIENCES

Environmental Epidemiology Pub Date : 2025-01-09 eCollection Date: 2025-02-01 DOI:10.1097/EE9.0000000000000365

Natalie R Binczewski, Libby M Morimoto, Joseph L Wiemels, Xiaomei Ma, Catherine Metayer, Verónica M Vieira

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Abstract

Background: Few studies have investigated associations between per- and polyfluoroalkyl substances (PFAS) and childhood cancers. Detectable levels of PFAS in California water districts were reported in the Third Unregulated Contaminant Monitoring Rule for 2013-2015.

Methods: Geocoded residences at birth were linked to corresponding water district boundaries for 10,220 California-born children (aged 0-15 years) diagnosed with cancers (2000-2015) and 29,974 healthy controls. A pharmacokinetic model was used to predict average steady-state maternal serum concentrations of perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) from contaminated drinking water. Adjusted odds ratios (AORs) and 95% confidence intervals (CIs) per doubling of background exposure were calculated for cancers with at least 90 cases.

Results: Predicted PFOS and PFOA maternal serum concentrations ranged from background (5 ng/ml PFOS and 2 ng/ml PFOA) to 22.89 ng/ml and 6.66 ng/ml, respectively. There were suggestive associations between PFOS and nonastrocytoma gliomas (n = 268; AOR = 1.26; 95% CI: 0.99, 1.60), acute myeloid leukemia (n = 500; AOR = 1.14; 95% CI: 0.94, 1.39), Wilms tumors (n = 556, AOR = 1.15; 95% CI: 0.96, 1.38), and noncentral system embryonal tumors (n = 2,880; AOR = 1.07; 95% CI: 0.98, 1.17), and between PFOA and non-Hodgkin lymphoma (n = 384; AOR = 1.19; 95% CI: 0.95, 1.49). Among children of Mexico-born mothers, there was increased risk of Wilms tumor (n = 101; AOR_PFOS = 1.52; 95% CI: 1.06, 2.18; AOR_PFOA = 1.59, 95% CI: 1.12, 2.24) and noncentral system embryonal tumors (n = 557; AOR_PFOS = 1.24, 95% CI: 1.03, 1.50; AOR_PFOA = 1.19, 95% CI: 0.98, 1.45).

Conclusion: Results suggest associations between predicted prenatal maternal PFAS serum concentrations and some childhood cancers. Future analyses are warranted.

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2000-2015年加州产前暴露于受污染的水中的全氟烷基和多氟烷基物质（PFAS）与儿童癌症风险

背景：很少有研究调查了全氟烷基和多氟烷基物质（PFAS）与儿童癌症之间的关系。2013-2015年第三次不受管制污染物监测规则报告了加州水区PFAS的可检测水平。方法：10,220名加州出生的诊断为癌症的儿童（0-15岁）（2000-2015年）和29,974名健康对照者在出生时的地理编码居住地与相应的水区边界相关联。采用药代动力学模型预测受污染饮用水中全氟辛烷磺酸（PFOS）和全氟辛酸（PFOA）的平均稳态母体血清浓度。对至少90例的癌症计算每加倍背景暴露的调整优势比（AORs）和95%置信区间（CIs）。结果：预测PFOS和PFOA母体血清浓度范围分别为背景（5 ng/ml PFOS和2 ng/ml PFOA）至22.89 ng/ml和6.66 ng/ml。全氟辛烷磺酸与非星形细胞瘤胶质瘤之间存在相关性(n = 268；Aor = 1.26；95% CI: 0.99, 1.60)，急性髓性白血病(n = 500；Aor = 1.14；95% CI: 0.94, 1.39)， Wilms肿瘤(n = 556, AOR = 1.15；95% CI: 0.96, 1.38)和非中枢系统胚胎性肿瘤(n = 2,880；Aor = 1.07；95% CI: 0.98, 1.17)， PFOA与非霍奇金淋巴瘤(n = 384；Aor = 1.19；95% ci: 0.95, 1.49)。在墨西哥出生的母亲的孩子中，患肾母细胞瘤的风险增加(n = 101；Aorpfos = 1.52；95% ci: 1.06, 2.18；orpfoa = 1.59, 95% CI: 1.12, 2.24)和非中枢系统胚胎性肿瘤(n = 557；orpfos = 1.24, 95% ci: 1.03, 1.50；orpfoa = 1.19, 95% ci: 0.98, 1.45)。结论：结果提示预测产前母体PFAS血清浓度与某些儿童癌症存在关联。未来的分析是有必要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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