The emerging landscape of small nucleolar RNA host gene 10 in cancer mechanistic insights and clinical relevance

IF 4.4 2区生物学 Q2 CELL BIOLOGY

Cellular signalling Pub Date : 2025-01-10 DOI:10.1016/j.cellsig.2025.111590

Jingyu Zhu , Zihao Jian , Fangteng Liu , Lulu Le

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引用次数: 0

Abstract

Small nucleolar RNA host gene 10 (SNHG10) is a newly recognized long non-coding RNA (lncRNA) with significant implications in cancer biology. Abnormal expression of SNHG10 has been observed in various solid tumors and hematological malignancies. Research conducted in vivo and in vitro has revealed that SNHG10 plays a pivotal role in numerous biological processes, including cell proliferation, apoptosis, invasion and migration, drug resistance, energy metabolism, immune evasion, as well as tumor growth and metastasis. SNHG10 regulates tumor development through several mechanisms, such as competing with microRNA (miRNA) for binding sites, modulating various signaling pathways, influencing transcriptional activity, and affecting epigenetic regulation. The diverse biological functions and intricate mechanisms of SNHG10 highlight its considerable clinical relevance, positioning it as a potential pan-cancer biomarker and therapeutic target. This review aims to summarize the role of SNHG10 in tumorigenesis and cancer progression, clarify the molecular mechanisms at play, and explore its clinical significance in cancer diagnosis and prognosis prediction, along with its therapeutic potential.

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新兴景观小核核RNA宿主基因10在癌症的机制见解和临床相关性。

小核果RNA宿主基因10 （SNHG10）是一种新发现的长链非编码RNA (lncRNA)，在肿瘤生物学中具有重要意义。SNHG10在多种实体瘤和血液系统恶性肿瘤中均有异常表达。体内和体外研究表明，SNHG10在细胞增殖、凋亡、侵袭迁移、耐药、能量代谢、免疫逃逸、肿瘤生长和转移等众多生物学过程中发挥着关键作用。SNHG10通过与microRNA （miRNA）竞争结合位点、调节多种信号通路、影响转录活性、影响表观遗传调控等多种机制调控肿瘤发展。SNHG10多样的生物学功能和复杂的机制凸显了其巨大的临床意义，使其成为潜在的泛癌症生物标志物和治疗靶点。本文旨在总结SNHG10在肿瘤发生和肿瘤进展中的作用，阐明其分子机制，探讨其在肿瘤诊断和预后预测中的临床意义及治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular signalling 生物-细胞生物学

CiteScore

8.40

自引率

0.00%

发文量

250

审稿时长

27 days

期刊介绍： Cellular Signalling publishes original research describing fundamental and clinical findings on the mechanisms, actions and structural components of cellular signalling systems in vitro and in vivo. Cellular Signalling aims at full length research papers defining signalling systems ranging from microorganisms to cells, tissues and higher organisms.