Neuronal theta oscillation of hippocampal ensemble and memory function.

Abstract

Memory is the ability to acquire and store information following an experience, which can be retrieved by related context exposure. Pioneering studies have demonstrated that sparsely distributed neuronal ensembles or engram cells can serve as neural substrates for storing and recalling memory traces. Many studies of neuronal ensembles have focused on the hippocampus, and increasing evidence has indicated that the neuronal oscillation is closely associated with hippocampal memory functions, including both encoding and retrieval processes. In particular, the theta synchronization of hippocampal ensembles with other brain regions mediates the retrieval of multiple types of memory. The recent progress of theta oscillations in the formation of memory engrams is reviewed, as well as the increased theta power and neurotransmitter regulation on memory function. Detailed information based on an analysis of hippocampal local theta rhythms is presented. Moreover, the hippocampus theta synchronization with the sensory cortex, prefrontal cortex and amygdala, which mediate different types of memory retrieval, are also reviewed. Together, these findings contribute to understanding the important role of hippocampal theta oscillation in the storage and recall of memory traces.