The multifaceted role of SMAD4 in immune cell function

IF 2.3 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry and Biophysics Reports Pub Date : 2024-12-18 DOI:10.1016/j.bbrep.2024.101902

Xinmu Cui , Yu Song , Jianfeng Han , Zhaoxin Yuan

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引用次数: 0

Abstract

The Transforming Growth Factor-beta (TGF-β) signaling pathway, with SMAD4 as its central mediator, plays a pivotal role in regulating cellular functions, including growth, differentiation, apoptosis, and immune responses. While extensive research has elucidated SMAD4's role in tumorigenesis, its functions within immune cells remain underexplored. This review synthesizes current knowledge on SMAD4's diverse roles in various immune cells such as T cells, B cells, dendritic cells, and macrophages, highlighting its impact on immune homeostasis and pathogen response. Understanding SMAD4's role in immune cells is crucial, as its dysregulation can lead to autoimmune disorders, chronic inflammation, and immune deficiencies. The review emphasizes the significance of SMAD4 in immune regulation, proposing that deeper investigation could reveal novel therapeutic targets for immune-mediated conditions. Insights into SMAD4's involvement in processes like T cell differentiation, B cell class switch recombination, and macrophage polarization underscore its potential as a therapeutic target for a range of diseases, including autoimmune disorders and cancer.

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SMAD4在免疫细胞功能中的多方面作用。

转化生长因子-β (TGF-β)信号通路以SMAD4为中心介质，在调节细胞功能，包括生长、分化、凋亡和免疫应答中起关键作用。虽然广泛的研究已经阐明了SMAD4在肿瘤发生中的作用，但其在免疫细胞中的功能仍未被充分探索。本文综述了SMAD4在T细胞、B细胞、树突状细胞和巨噬细胞等多种免疫细胞中的作用，重点介绍了SMAD4对免疫稳态和病原体反应的影响。了解SMAD4在免疫细胞中的作用是至关重要的，因为它的失调会导致自身免疫性疾病、慢性炎症和免疫缺陷。这篇综述强调了SMAD4在免疫调节中的重要意义，并建议对其进行更深入的研究，以揭示免疫介导疾病的新治疗靶点。对SMAD4参与T细胞分化、B细胞类别转换重组和巨噬细胞极化等过程的深入研究，强调了SMAD4作为一系列疾病（包括自身免疫性疾病和癌症）的治疗靶点的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochemistry and Biophysics Reports Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

4.60

自引率

0.00%

发文量

191

审稿时长

59 days

期刊介绍： Open access, online only, peer-reviewed international journal in the Life Sciences, established in 2014 Biochemistry and Biophysics Reports (BB Reports) publishes original research in all aspects of Biochemistry, Biophysics and related areas like Molecular and Cell Biology. BB Reports welcomes solid though more preliminary, descriptive and small scale results if they have the potential to stimulate and/or contribute to future research, leading to new insights or hypothesis. Primary criteria for acceptance is that the work is original, scientifically and technically sound and provides valuable knowledge to life sciences research. We strongly believe all results deserve to be published and documented for the advancement of science. BB Reports specifically appreciates receiving reports on: Negative results, Replication studies, Reanalysis of previous datasets.