Causal inference with cross-temporal design.

IF 1.4 4区 数学 Q3 BIOLOGY
Biometrics Pub Date : 2025-01-07 DOI:10.1093/biomtc/ujae163
Yi Cao, Pedro L Gozalo, Roee Gutman
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引用次数: 0

Abstract

When many participants in a randomized trial do not comply with their assigned intervention, the randomized encouragement design is a possible solution. In this design, the causal effects of the intervention can be estimated among participants who would have experienced the intervention if encouraged. For many policy interventions, encouragements cannot be randomized and investigators need to rely on observational data. To address this, we propose a cross-temporal design, which uses time to mimic a randomized encouragement experiment. However, time may be confounded with temporal trends that influence the outcomes. To disentangle these trends from the intervention effects, we replace the commonly used exclusion restrictions with temporal assumptions. We develop Bayesian procedures to estimate the causal effects and compare it to instrumental variables and matching approaches in simulations. The Bayesian approach outperforms the other 2 approaches in terms of estimation accuracy, and it is relatively robust to various violations of the common trends assumption. Taking advantage of the expansion of the Medicare Advantage (MA) program between 2011 and 2017, we implement the proposed method to estimate the effects of MA enrollment on the risk of skilled nursing facility residents being re-hospitalized within 30 days after discharge from the hospital.

跨时间设计的因果推理。
当随机试验中的许多参与者不遵守分配的干预措施时,随机鼓励设计是一种可能的解决方案。在这个设计中,干预的因果效应可以在参与者中估计,如果鼓励的话,他们会经历干预。对于许多政策干预,鼓励措施不能是随机的,调查人员需要依靠观察数据。为了解决这个问题,我们提出了一个跨时间设计,它使用时间来模拟随机鼓励实验。但是,时间可能与影响结果的时间趋势相混淆。为了将这些趋势与干预效应区分开来,我们用时间假设取代了常用的排除限制。我们开发了贝叶斯程序来估计因果效应,并将其与模拟中的工具变量和匹配方法进行比较。贝叶斯方法在估计精度方面优于其他两种方法,并且对各种违反共同趋势假设的情况具有相对的鲁棒性。利用2011年至2017年间医疗保险优势(MA)计划的扩大,我们实施了所提出的方法来估计MA登记对熟练护理机构居民出院后30天内再次住院风险的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biometrics
Biometrics 生物-生物学
CiteScore
2.70
自引率
5.30%
发文量
178
审稿时长
4-8 weeks
期刊介绍: The International Biometric Society is an international society promoting the development and application of statistical and mathematical theory and methods in the biosciences, including agriculture, biomedical science and public health, ecology, environmental sciences, forestry, and allied disciplines. The Society welcomes as members statisticians, mathematicians, biological scientists, and others devoted to interdisciplinary efforts in advancing the collection and interpretation of information in the biosciences. The Society sponsors the biennial International Biometric Conference, held in sites throughout the world; through its National Groups and Regions, it also Society sponsors regional and local meetings.
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