Outcomes of dietary interventions in the prevention and progression of Parkinson's disease: A literature review.

IF 3.1 Q2 NEUROSCIENCES
AIMS Neuroscience Pub Date : 2024-12-30 eCollection Date: 2024-01-01 DOI:10.3934/Neuroscience.2024032
Ubaid Ansari, Alexi Omid, Dawnica Nadora, Jimmy Wen, Arman Omid, Forshing Lui
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引用次数: 0

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms, primarily due to the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Factors contributing to this neuronal degeneration include mitochondrial dysfunction, oxidative stress, and neuronal excitotoxicity. Despite extensive research, the exact etiology of PD remains unclear, with both genetic and environmental factors playing significant roles. Given the increasing prevalence of PD, particularly in aging populations, effective preventive and therapeutic strategies are urgently needed. Emerging research suggests that dietary interventions might offer promising approaches to managing PD progression. This literature review examines various dietary interventions that differ in their composition and mechanisms of action, including the Mediterranean, vegan, carnivore, paleo, and ketogenic diets, and their potential neuroprotective effects. By evaluating the current evidence, this review aims to identify dietary strategies that may improve the quality of life for individuals with PD. Additionally, it explores the underlying mechanisms through which diet may influence PD pathophysiology, thus providing insights into how nutritional modifications can be integrated into holistic management plans for the disease.

饮食干预在帕金森病预防和进展中的结果:文献综述
帕金森病(PD)是一种以运动和非运动症状为特征的进行性神经退行性疾病,主要是由于黑质致密部(SNpc)多巴胺能神经元的退化。导致这种神经元变性的因素包括线粒体功能障碍、氧化应激和神经元兴奋性毒性。尽管进行了广泛的研究,但PD的确切病因尚不清楚,遗传和环境因素都起着重要作用。鉴于帕金森病的发病率不断上升,特别是在老年人群中,迫切需要有效的预防和治疗策略。新兴研究表明,饮食干预可能为控制PD进展提供有希望的方法。这篇文献综述考察了各种不同的饮食干预,包括地中海饮食、纯素饮食、食肉饮食、古饮食和生酮饮食,以及它们潜在的神经保护作用。通过评估目前的证据,本综述旨在确定可能改善PD患者生活质量的饮食策略。此外,它还探讨了饮食可能影响PD病理生理的潜在机制,从而为如何将营养调整整合到疾病的整体管理计划中提供了见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
AIMS Neuroscience
AIMS Neuroscience NEUROSCIENCES-
CiteScore
4.20
自引率
0.00%
发文量
26
审稿时长
8 weeks
期刊介绍: AIMS Neuroscience is an international Open Access journal devoted to publishing peer-reviewed, high quality, original papers from all areas in the field of neuroscience. The primary focus is to provide a forum in which to expedite the speed with which theoretical neuroscience progresses toward generating testable hypotheses. In the presence of current and developing technology that offers unprecedented access to functions of the nervous system at all levels, the journal is designed to serve the role of providing the widest variety of the best theoretical views leading to suggested studies. Single blind peer review is provided for all articles and commentaries.
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