An eco-evolutionary perspective on antimicrobial resistance in the context of One Health

IF 4.6 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience Pub Date : 2025-01-17 DOI:10.1016/j.isci.2024.111534

Misshelle Bustamante , Siyu Mei , Ines M. Daras , G.S. van Doorn , Joana Falcao Salles , Marjon G.J. de Vos

引用次数: 0

Abstract

The One Health approach musters growing concerns about antimicrobial resistance due to the increased use of antibiotics in healthcare and agriculture, with all of its consequences for human, livestock, and environmental health. In this perspective, we explore the current knowledge on how interactions at different levels of biological organization, from genetic to ecological interactions, affect the evolution of antimicrobial resistance. We discuss their role in different contexts, from natural systems with weak selection, to human-influenced environments that impose a strong pressure toward antimicrobial resistance evolution. We emphasize the need for an eco-evolutionary approach within the One Health framework and highlight the importance of horizontal gene transfer and microbiome interactions for increased understanding of the emergence and spread of antimicrobial resistance.

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在同一个健康的背景下，对抗菌素耐药性的生态进化观点。

“同一个健康”方针引起了人们对抗菌素耐药性的日益关注，这是由于在卫生保健和农业中抗生素使用的增加，以及对人类、牲畜和环境健康的所有后果。从这个角度来看，我们探索了目前关于生物组织不同水平的相互作用（从遗传到生态相互作用）如何影响抗菌素耐药性进化的知识。我们讨论了它们在不同背景下的作用，从自然系统的弱选择，到人类影响的环境，对抗菌素耐药性进化施加了强大的压力。我们强调需要在“同一个健康”框架内采用生态进化方法，并强调水平基因转移和微生物组相互作用对于增加对抗菌素耐药性的出现和传播的理解的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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