Quantitative assessment of transmural remission in Crohn's disease using low dose computed tomography (CT) enterography perfusion imaging: a single-centre study based on intestinal microcirculation

IF 2.1 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical radiology Pub Date : 2025-02-01 DOI:10.1016/j.crad.2024.106786

H.-J. Tu , Q.-Q. Chen , X. Chen , J.-C. Tu , J.-T. Cao , F. Zhu , C.-H. Hu

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Abstract

AIM

To assess transmural remission in patients with Crohn's disease using low-dose small bowel computed tomography (CT) perfusion scans.

MATERIALS AND METHODS

Forty six patients were divided into active and remission phases based on Crohn's Disease Activity Index (CDAI) and C-reactive protein (CRP). Dual-source CT enterography with low-dose perfusion scans was conducted to generate perfusion parameter maps, including blood flow (BF), blood volume (BV), time to peak (TTP), mean transit time (MTT), and permeability of surface (PS). We compared differences in perfusion parameter values of intestinal walls, mesenteric fat, and lymph nodes between two groups. Receiver operating characteristic (ROC) curves were plotted, and area under the curve (AUC), sensitivity, specificity, and cutoff values were calculated.

RESULTS

The BF, BV, TTP, MTT, and PS values of the intestinal wall were significantly higher in the active phase (P0.05). Additionally, lymph node BF and TTP displayed significant differences (P<0.01).

CONCLUSION

Dual-source CT enterography with low-dose perfusion scans enables quantitative assessment of Crohn's disease microcirculation in intestinal walls, mesenteric fat, and lymph nodes. These quantitative indicators provide strong diagnostic efficacy and offer insights into whether the disease is in transmural remission.

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使用低剂量计算机断层扫描（CT）肠造影灌注成像定量评估克罗恩病的跨壁缓解：基于肠道微循环的单中心研究

目的：利用低剂量小肠计算机断层扫描（CT）灌注扫描评估克罗恩病患者的跨壁缓解。材料与方法：根据克罗恩病活动性指数（CDAI）和c反应蛋白（CRP）将46例患者分为活动期和缓解期。采用双源CT肠造影低剂量灌注扫描生成灌注参数图，包括血流量（BF）、血容量（BV）、到达峰值时间（TTP）、平均传递时间（MTT）、表面通透性（PS）。比较两组肠壁、肠系膜脂肪和淋巴结灌注参数值的差异。绘制受试者工作特征（ROC）曲线，计算曲线下面积（AUC）、敏感性、特异性和截止值。结果：活动期肠壁的BF、BV、TTP、MTT、PS值均显著升高（P0.05）。此外，淋巴结BF和TTP也有显著差异(p)。结论：双源CT肠造影结合低剂量灌注扫描可以定量评估肠壁、肠系膜脂肪和淋巴结的克罗恩病微循环。这些定量指标提供了强大的诊断效力，并为疾病是否处于跨壁缓解提供了见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical radiology 医学-核医学

CiteScore

4.70

自引率

3.80%

发文量

528

审稿时长

76 days

期刊介绍： Clinical Radiology is published by Elsevier on behalf of The Royal College of Radiologists. Clinical Radiology is an International Journal bringing you original research, editorials and review articles on all aspects of diagnostic imaging, including: • Computed tomography • Magnetic resonance imaging • Ultrasonography • Digital radiology • Interventional radiology • Radiography • Nuclear medicine Papers on radiological protection, quality assurance, audit in radiology and matters relating to radiological training and education are also included. In addition, each issue contains correspondence, book reviews and notices of forthcoming events.