Analysis of healthcare utilization before the diagnosis of radiologically isolated syndrome.

IF 4.8 2区医学 Q1 CLINICAL NEUROLOGY

Multiple Sclerosis Journal Pub Date : 2025-02-01 Epub Date: 2025-01-10 DOI:10.1177/13524585241291471

Christine Lebrun-Frenay, Sandrine Kerbrat, Darin T Okuda, Cassandre Landes-Chateau, Orhun H Kantarci, Chloe Pierret, Erwan Drezen, Emmanuel Nowak, Aksel Siva, Christina J Azevedo, Mikael Cohen, Emmanuelle Leray

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引用次数: 0

Abstract

Background: Previous studies have shown that people with multiple sclerosis (MS) had frequent healthcare visits up to 10 years before being diagnosed but with no information from magnetic resonance imaging (MRI) scans of the connection with the radiologically isolated syndrome (RIS).

Objective: To analyze healthcare use 3 years before the RIS diagnosis.

Methods: We examined healthcare usage before the first scan in RIS cases from 2010 to 2019. RIS subjects were identified from the French National MS observatory and compared to the general population (matched 10:1) and MS patients (matched 4:1).

Results: Among 482 RIS individuals, 223 (46.3%) were not linked to the healthcare resources database. The remaining RIS individuals (53.7%) had higher healthcare usage before their RIS diagnosis for issues related to neurology visits, headaches (odds ratio (OR): 3.34, confidence interval (CI): [2.00-5.57], p < 0.0001), and the use of anti-migraine drugs (OR: 2.61, CI: [1.37-4.99], p = 0.004) compared to MS.

Conclusion: Only about half of RIS patients had MS-selected healthcare resources, which allowed for data linkage. Those who did seek care before their RIS diagnosis were most commonly known for other neurological comorbidities. These findings do not support the idea of a systemic prodrome before RIS diagnosis.

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放射孤立综合征诊断前的医疗保健利用分析。

背景：先前的研究表明，多发性硬化症（MS）患者在确诊前10年有频繁的医疗保健访问，但没有从磁共振成像（MRI）扫描与放射孤立综合征（RIS）的联系中获得信息。目的：分析RIS诊断前3年的医疗保健使用情况。方法：我们在2010年至2019年首次扫描RIS病例前检查医疗保健使用情况。RIS受试者来自法国国家多发性硬化症观测站，并与普通人群（匹配比例为10:1）和多发性硬化症患者（匹配比例为4:1）进行比较。结果：在482名RIS个体中，223名（46.3%）未与医疗资源数据库连接。与ms相比，其余RIS患者（53.7%）在接受RIS诊断前，因神经病学就诊、头痛（优势比（OR）： 3.34，置信区间（CI）： [2.00-5.57], p < 0.0001）和抗偏头痛药物的使用（OR: 2.61, CI: [1.37-4.99], p = 0.004）等问题的医疗保健使用率较高。结论：只有约一半的RIS患者使用ms选择的医疗保健资源，这允许数据链接。那些在RIS诊断前寻求治疗的人最常见的是其他神经合并症。这些发现不支持RIS诊断前存在全身性前驱症状的观点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Multiple Sclerosis Journal 医学-临床神经学

CiteScore

10.90

自引率

6.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system. The journal for your research in the following areas: * __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics * __Epidemology and genetics:__ genetics epigenetics, epidemiology * __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures * __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management Print ISSN: 1352-4585