The Role of Exercise-Based Cardiac Rehabilitation After Myocardial Infarction on Cholesterol Transfer to HDL.

IF 5.6 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-01-06 DOI:10.3390/ijms26010419

Jose C Nicolau, Talia F Dalcoquio, Roberto R Giraldez, Fatima R Freitas, Andre M Nicolau, Remo H M Furtado, Thauany M Tavoni, Luciano M Baracioli, Felipe G Lima, Aline G Ferrari, Maria U P B Rondon, Rocio Salsoso, Maria J N N Alves, Flavia B B Arantes, Mayara A Santos, Leandro S Alves, Carlos E Negrao, Raul C Maranhão

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引用次数: 0

Abstract

High-density lipoprotein (HDL) is associated with decreased incidence of cardiovascular events, and its functionality also influences prognosis. Exercise is an important tool to improve prognosis in the post-infarction (MI) population, but the role of exercise on HDL functionality is poorly understood. Sixty-two patients with acute MI were randomized in a supervised exercise program for 12-14 weeks (exercise group-EG) or a control group (CG). The main objective of the study was to analyze the role of exercise on esterified cholesterol (EC) and unesterified cholesterol (UC) transfer to HDL. For the total population, the baseline mean rate of EC transfer to HDL was 2.53 ± 0.83 and at the end of follow-up, it was 2.74 ± 0.64 (p = 0.03). The figures for UC were, respectively, 4.08 ± 1.2 and 4.4 ± 1.06 (p = 0.02). The difference (follow-up minus baseline) for EC was 0.15 ± 0.84 for the control group and 0.27 ± 0.69 for the exercise group (p = 0.53); for UC, the figures were 0.28 ± 1.14 and 0.35 ± 0.96 (p = 0.80), respectively, for the control and exercise groups. In post-MI patients, 12-14 weeks of supervised exercise did not improve HDL functionality.

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心肌梗死后以运动为基础的心脏康复对胆固醇向HDL转移的作用

高密度脂蛋白（HDL）与心血管事件发生率的降低有关，其功能也影响预后。运动是改善心肌梗塞（MI）后人群预后的重要工具，但人们对运动对高密度脂蛋白功能的作用还知之甚少。62名急性心肌梗塞患者被随机分配到一个为期12-14周的有指导的运动计划中（运动组-EG）或对照组（CG）。研究的主要目的是分析运动对酯化胆固醇（EC）和未酯化胆固醇（UC）向高密度脂蛋白转移的作用。在所有人群中，酯化胆固醇转移至高密度脂蛋白的基线平均比率为 2.53 ± 0.83，而在随访结束时，这一比率为 2.74 ± 0.64（p = 0.03）。UC 的数字分别为 4.08 ± 1.2 和 4.4 ± 1.06（p = 0.02）。对照组的EC差异（随访减去基线）为0.15 ± 0.84，运动组为0.27 ± 0.69（p = 0.53）；对照组和运动组的UC差异（随访减去基线）分别为0.28 ± 1.14和0.35 ± 0.96（p = 0.80）。在心肌梗死后的患者中，12-14 周的有指导运动并不能改善高密度脂蛋白的功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Molecular Sciences 化学-化学综合

自引率

10.70%

发文量

13472

审稿时长

1.7 months

期刊介绍： The International Journal of Molecular Sciences (ISSN 1422-0067) provides an advanced forum for chemistry, molecular physics (chemical physics and physical chemistry) and molecular biology. It publishes research articles, reviews, communications and short notes. Our aim is to encourage scientists to publish their theoretical and experimental results in as much detail as possible. Therefore, there is no restriction on the length of the papers or the number of electronics supplementary files. For articles with computational results, the full experimental details must be provided so that the results can be reproduced. Electronic files regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material (including animated pictures, videos, interactive Excel sheets, software executables and others).