Bone marrow mesenchymal stem cells ameliorate diet-induced obesity by activating thermogenesis and alleviating inflammation in adipose tissue.

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemical and biophysical research communications Pub Date : 2025-02-02 Epub Date: 2024-12-20 DOI:10.1016/j.bbrc.2024.151172

Yanxue Wang, Jingfei Fu, Wanghong He, Yike Gao, Juan Du, Junji Xu, Lijia Guo, Yi Liu

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引用次数: 0

Abstract

Obesity and its related metabolic disorders seriously threaten our health and significantly reduce our life expectancy. The aim of the present study was to explore the effects of bone marrow mesenchymal stem cells (BMSCs) on high-fat diet (HFD)-induced obesity mice. The results demonstrated that BMSCs significantly reduced body weight, improved glucose tolerance and insulin sensitivity in obese mice. Further analysis showed that BMSCs could promote brown adipose tissue (BAT) activity and white adipose tissue (WAT) browning by increasing the expression of mitochondrial uncouple protein 1 (UCP1). Additionally, BMSCs markedly increase mitochondrial biogenesis, activate oxidative phosphorylation (OXPHOS) in adipose tissue, further contributing to energy metabolism regulation. Moreover, BMSCs were effective in inhibiting macrophage-related inflammation in adipose tissue, thereby mitigating obesity-associated inflammatory responses. Overall, our results lay the foundation for research on the potential of BMSCs as a promising strategy in alleviating obesity and related metabolic diseases.

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骨髓间充质干细胞通过激活产热和减轻脂肪组织的炎症来改善饮食诱导的肥胖。

肥胖及其相关的代谢紊乱严重威胁着我们的健康，并显著降低我们的预期寿命。本研究旨在探讨骨髓间充质干细胞（BMSCs）对高脂饮食（HFD）诱导的肥胖小鼠的影响。结果表明，骨髓间充质干细胞显著降低肥胖小鼠的体重，改善葡萄糖耐量和胰岛素敏感性。进一步分析表明，骨髓间质干细胞可通过增加线粒体解偶联蛋白1 （UCP1）的表达，促进棕色脂肪组织（BAT）活性和白色脂肪组织（WAT）褐变。此外，骨髓间充质干细胞显著增加线粒体生物发生，激活脂肪组织中的氧化磷酸化（OXPHOS），进一步促进能量代谢调节。此外，骨髓间充质干细胞能有效抑制脂肪组织中巨噬细胞相关的炎症，从而减轻肥胖相关的炎症反应。总之，我们的结果为研究骨髓间充质干细胞作为减轻肥胖和相关代谢疾病的有希望的策略的潜力奠定了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochemical and biophysical research communications 生物-生化与分子生物学

CiteScore

6.10

自引率

0.00%

发文量

1400

审稿时长

14 days

期刊介绍： Biochemical and Biophysical Research Communications is the premier international journal devoted to the very rapid dissemination of timely and significant experimental results in diverse fields of biological research. The development of the "Breakthroughs and Views" section brings the minireview format to the journal, and issues often contain collections of special interest manuscripts. BBRC is published weekly (52 issues/year).Research Areas now include: Biochemistry; biophysics; cell biology; developmental biology; immunology ; molecular biology; neurobiology; plant biology and proteomics