A Customized Janus Hydrogel with Robust Bio‐Adhesion and Multi‐Mode Disinfection for Rapid Recovery of Multi‐Drug‐Resistant Staphylococcus aureus‐Infected Open Wounds

IF 18.5 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Functional Materials Pub Date : 2025-01-11 DOI:10.1002/adfm.202420443

Danning Yan, Xiangmei Liu, Congyang Mao, Chaofeng Wang, Hanpeng Liu, Zhaoyang Li, Shengli Zhu, Hui Jiang, Zhenduo Cui, Yufeng Zheng, Shuilin Wu

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引用次数: 0

Abstract

Open wounds damage the integrity of the injured tissues and expose them to bacterial infections. Traditional wounds suturing often lead to the reinjuring of the damaged tissues. This delays the healing process, especially in the presence of a bacterial infection. A Janus hydrogel adhesive with bio‐adhesion and multi‐mode disinfection (BAMD) capabilities (a BAMD hydrogel) is developed using a spin‐coating process, which can serve as an alternative to traditional sutures. The organic–inorganic hybrid combination of the Chinese‐medicine organic small molecule rhein (Rhe) and graphene oxide (GO) endows the BAMD hydrogel with dual‐mode antibacterial activity driven by photodynamic (PD) and photothermal (PT) effects including short‐term rapid disinfection (15‐min irradiation, with a 99.95% bactericidal rate) and long‐term antibacterial action in the absence of light (100% bactericidal rate after 6 h of dark incubation). The in vivo results demonstrated a 97.25% bactericidal rate of the BAMD hydrogel against MRSA. Throughout the wound recovery process, the BAMD hydrogel effectively reduced inflammation and promoted tissue healing. This versatile strategy offers new insights into preventing postoperative tissue adhesion and sealing and repairing large‐scale tissue damage.

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一种定制的Janus水凝胶，具有强大的生物粘附性和多模式消毒，用于多种耐药金黄色葡萄球菌感染的开放性伤口的快速恢复

开放性伤口会破坏受伤组织的完整性，使其容易受到细菌感染。传统的伤口缝合往往导致损伤组织的再损伤。这会延迟愈合过程，特别是在存在细菌感染的情况下。采用自旋涂层工艺开发了具有生物粘附和多模式消毒（BAMD）能力的Janus水凝胶粘合剂（BAMD水凝胶），可作为传统缝合线的替代品。中药有机小分子大黄酸（Rhe）和氧化石墨烯（GO）的有机-无机杂交组合使BAMD水凝胶具有光动力（PD）和光热（PT）效应驱动的双模式抗菌活性，包括短期快速消毒（照射15分钟，杀菌率99.95%）和长期无光抗菌作用（黑暗孵育6小时后杀菌率100%）。体内实验结果表明，BAMD水凝胶对MRSA的杀菌率为97.25%。在整个伤口恢复过程中，BAMD水凝胶有效地减少炎症，促进组织愈合。这种多用途的策略为防止术后组织粘连和密封以及修复大规模组织损伤提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Functional Materials 工程技术-材料科学：综合

CiteScore

29.50

自引率

4.20%

发文量

2086

审稿时长

2.1 months

期刊介绍： Firmly established as a top-tier materials science journal, Advanced Functional Materials reports breakthrough research in all aspects of materials science, including nanotechnology, chemistry, physics, and biology every week. Advanced Functional Materials is known for its rapid and fair peer review, quality content, and high impact, making it the first choice of the international materials science community.