Effect of cryoablation on the spatial transcriptomic landscape of the immune microenvironment in non-small cell lung cancer.

Journal of cancer research and therapeutics Pub Date : 2024-12-01 Epub Date: 2025-01-10 DOI:10.4103/jcrt.jcrt_1887_24

Jun Zhou, Shengxi Wang, Ming Liu, Zhaopei Li

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Abstract

Background: Cryoablation induces antitumor immune responses. Spatial transcriptomic landscape technology has been used to determine the micron-level panoramic transcriptomics of tissue slices in situ.

Methods: The effects of cryoablation on the immune microenvironment in non-small cell lung cancer (NSCLC) were explored by comparing the Whole Transcriptome Atlas (WTA) panel of immune cells before and after cryoablation using the spatial transcriptomic landscape.

Results: The bioinformatics analysis showed that cryoablation significantly affected the WTA of immune cells, particularly genes related to cellular components, biological processes, molecular functions, proliferation and migration, and cytokine-cytokine receptor interaction signaling pathways.

Conclusions: The findings of this study suggest that cryoablation significantly impacts the biological functions of immune cells in the tumor microenvironment of NSCLC through multiple mechanisms.

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低温消融对非小细胞肺癌免疫微环境空间转录组景观的影响

背景：冷冻消融术诱导抗肿瘤免疫反应。空间转录组景观技术已被用于确定微米级全景转录组原位组织切片。方法：利用空间转录组景观，通过比较冰冻消融前后免疫细胞的全转录组图谱（Whole Transcriptome Atlas， WTA），探讨冰冻消融对非小细胞肺癌（NSCLC）免疫微环境的影响。结果：生物信息学分析显示，冷冻消融显著影响免疫细胞的WTA，特别是与细胞成分、生物过程、分子功能、增殖和迁移以及细胞因子-细胞因子受体相互作用信号通路相关的基因。结论：本研究结果提示，冷冻消融通过多种机制显著影响非小细胞肺癌肿瘤微环境中免疫细胞的生物学功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of cancer research and therapeutics

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