The P200 ERP Response in Mild Cognitive Impairment and the Aging Population.

David Oakley, David Joffe, Francis Palermo, Marta Spada, Sanjay Yathiraj
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Abstract

Evoked potential metrics extracted from an EEG exam can provide novel sources of information regarding brain function. While the P300 occurring around 300 ms post-stimulus has been extensively investigated in relation to mild cognitive impairment (MCI), with decreased amplitude and increased latency, the P200 response has not, particularly in an oddball-stimulus paradigm. This study compares the auditory P200 amplitudes between MCI (28 patients aged 74(8)) and non-MCI, (35 aged 72(4)). Data were collected in routine clinical evaluations where EEG with audio oddball ERPs were measured as part of a health screening exam from 2 clinics serving MCI patients and one clinic serving a non-MCI population as part of a wellness/preventative care program. We also investigated the disease course for 3 patients as case studies. The results revealed the P200 amplitudes to be significantly increased in the MCI compared to the non-MCI groups, alongside the expected reduction in P300, Trail Making, and reaction time. Moreover, the ratio of P200-to-P300 was also increased in the MCI groups even in cases where the P300 was strong. This trend continued for patients who were tracked from early-to-later stages in the case studies. While the pathophysiology of the P200 response in a 2-tone auditory oddball protocol is not well understood, this measure may help indicate signs of early MCI, particularly in cases where the P300 is still strong.

轻度认知障碍与老年人群的P200 ERP反应。
从脑电图检查中提取的诱发电位指标可以提供有关脑功能的新信息来源。虽然P300在刺激后300 ms左右出现与轻度认知障碍(MCI)的关系已被广泛研究,但P200的反应幅度下降,潜伏期增加,特别是在奇怪的刺激模式下。本研究比较了轻度认知损伤(28例74岁患者)和非轻度认知损伤(35例72岁患者)的听觉P200振幅。数据是在常规临床评估中收集的,其中脑电图与音频古怪的erp作为健康筛查检查的一部分,来自两个服务轻度认知障碍患者的诊所和一个服务非轻度认知障碍人群的诊所,作为健康/预防保健计划的一部分。我们还调查了3例患者的病程作为个案研究。结果显示,与非MCI组相比,MCI组的P200幅度显着增加,同时P300, Trail Making和反应时间也预期减少。此外,即使在P300较强的情况下,MCI组中p200与P300的比率也有所增加。这种趋势在病例研究中从早期到晚期被跟踪的患者中继续存在。虽然P200反应的病理生理学在双音听觉怪异协议中还没有很好地理解,但这种测量可能有助于指出早期轻度认知障碍的迹象,特别是在P300仍然很强的情况下。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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