Safira A Wortel, Ferishta Bakhshi-Raiez, Ameen Abu-Hanna, Dave A Dongelmans, Nicolette F de Keizer, Aletta Houwink, Allard Dijkhuizen, Annelies Draisma, Annemiek Rijkeboer, Arjan Cloïn, Arthur de Meijer, Auke Reidinga, Barbara Festen-Spanjer, Bas van Bussel, Bob Eikemans, Cretièn Jacobs, David Moolenaar, Dharmanand Ramnarain, Dick Koning, Dirk Boer, Dirk Verbiest, Eline van Slobbe-Bijlsma, Ellen van Koppen, Els Rengers, Erik van Driel, Eva Verweij, Freya van Iersel, Gert Brunnekreef, Hans Kieft, Herman Kreeftenberg, Ilanit Hené, Inge Janssen, Ionana Drogt, Iwan van der Horst, Jan Jaap Spijkstra, Jan Rozendaal, Jannet Mehagnoul-Schipper, Jelle Epker Erasmus, Jessica Holtkamp, Johan Lutisan, Jos van Oers, Judith Lens, Laura van Gulik, Lettie van den Berg, Louise Urlings-Strop, Lyuba Georgieva, Maarten van Lieshout, Marga Hoogendoorn, Marissa Vrolijk-de Mos, Mart de Graaff, Martha de Bruin, Martijn Hoeksema, Martijn van Tellingen, Michel Barnas, Michiel Erkamp, Niels Gritters, Nuray Kusadasi, Paul Elbers, Peter Koetsier, Peter Spronk, Peter van der Voort, Ralph Pruijsten, Remko de Jong, Robert-Jan Bosman, Ronald Wesselink, Ronny Schnabel, Roy van den Berg, Ruud de Waal, Sesmu Arbous, Silvia Knape, Stefaan Hendriks, Tim Frenzel, Tom Dormans, Tom Rijpstra, Vera Silderhuis, Wouter de Ruijter
{"title":"Long-term mortality of Dutch COVID-19 patients admitted to the intensive care medicine: a retrospective analysis from a national quality registry.","authors":"Safira A Wortel, Ferishta Bakhshi-Raiez, Ameen Abu-Hanna, Dave A Dongelmans, Nicolette F de Keizer, Aletta Houwink, Allard Dijkhuizen, Annelies Draisma, Annemiek Rijkeboer, Arjan Cloïn, Arthur de Meijer, Auke Reidinga, Barbara Festen-Spanjer, Bas van Bussel, Bob Eikemans, Cretièn Jacobs, David Moolenaar, Dharmanand Ramnarain, Dick Koning, Dirk Boer, Dirk Verbiest, Eline van Slobbe-Bijlsma, Ellen van Koppen, Els Rengers, Erik van Driel, Eva Verweij, Freya van Iersel, Gert Brunnekreef, Hans Kieft, Herman Kreeftenberg, Ilanit Hené, Inge Janssen, Ionana Drogt, Iwan van der Horst, Jan Jaap Spijkstra, Jan Rozendaal, Jannet Mehagnoul-Schipper, Jelle Epker Erasmus, Jessica Holtkamp, Johan Lutisan, Jos van Oers, Judith Lens, Laura van Gulik, Lettie van den Berg, Louise Urlings-Strop, Lyuba Georgieva, Maarten van Lieshout, Marga Hoogendoorn, Marissa Vrolijk-de Mos, Mart de Graaff, Martha de Bruin, Martijn Hoeksema, Martijn van Tellingen, Michel Barnas, Michiel Erkamp, Niels Gritters, Nuray Kusadasi, Paul Elbers, Peter Koetsier, Peter Spronk, Peter van der Voort, Ralph Pruijsten, Remko de Jong, Robert-Jan Bosman, Ronald Wesselink, Ronny Schnabel, Roy van den Berg, Ruud de Waal, Sesmu Arbous, Silvia Knape, Stefaan Hendriks, Tim Frenzel, Tom Dormans, Tom Rijpstra, Vera Silderhuis, Wouter de Ruijter","doi":"10.62675/2965-2774.20240251-en","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To describe the 12-month mortality of Dutch COVID-19 intensive care unit patients, the total COVID-19 population and various subgroups on the basis of the number of comorbidities, age, sex, mechanical ventilation, and vasoactive medication use.</p><p><strong>Methods: </strong>We included all patients admitted with COVID-19 between March 1, 2020, and March 29, 2022, from the Dutch National Intensive Care (NICE) database. The crude 12-month mortality rate is presented via Kaplan-Meier survival curves for each patient subgroup. We used Cox regression models to analyze the effects of patient characteristics on 12-month mortality after hospital discharge.</p><p><strong>Results: </strong>We included 16,605 COVID-19 patients. The in-hospital mortality rate was 28.1%, and the 12-month mortality rate after intensive care unit admission was 29.8%. Among hospital survivors, 12-month mortality after hospital discharge was 2.5% (300/11,931). The hazard of death at 12 months after hospital discharge was greater in patients between 60 and 79 years (HR 4.74; 95%CI 2.23 - 10.06) and ≥ 80 years (HR 22.77; 95%CI 9.91 - 52.28) than in patients < 40 years of age; in male patients than in female patients (HR 1.38; 95%CI 1.07 - 1.78); and in patients with one (adjusted HR 1.95; 95%CI 1.5 - 2.53), two (adjusted HR 4.49; 95%CI 3.27 - 6.16) or more than two comorbidities (adjusted HR 4.99; 95%CI 2.62 - 9.5) than in patients with no comorbidities. Neither vasoactive medication use nor mechanical ventilation resulted in statistically significant results.</p><p><strong>Conclusion: </strong>For Dutch COVID-19 intensive care unit patients, most deaths occurred during their hospital stay. For hospital survivors, the crude 12-month mortality rate was low. Patient age (older than 60), sex and the number of comorbidities were associated with a greater hazard of death at 12 months after hospital discharge, whereas mechanical ventilation and vasoactive medication were not.</p>","PeriodicalId":72721,"journal":{"name":"Critical care science","volume":"36 ","pages":"e202400251en"},"PeriodicalIF":0.0000,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11463994/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Critical care science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.62675/2965-2774.20240251-en","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To describe the 12-month mortality of Dutch COVID-19 intensive care unit patients, the total COVID-19 population and various subgroups on the basis of the number of comorbidities, age, sex, mechanical ventilation, and vasoactive medication use.
Methods: We included all patients admitted with COVID-19 between March 1, 2020, and March 29, 2022, from the Dutch National Intensive Care (NICE) database. The crude 12-month mortality rate is presented via Kaplan-Meier survival curves for each patient subgroup. We used Cox regression models to analyze the effects of patient characteristics on 12-month mortality after hospital discharge.
Results: We included 16,605 COVID-19 patients. The in-hospital mortality rate was 28.1%, and the 12-month mortality rate after intensive care unit admission was 29.8%. Among hospital survivors, 12-month mortality after hospital discharge was 2.5% (300/11,931). The hazard of death at 12 months after hospital discharge was greater in patients between 60 and 79 years (HR 4.74; 95%CI 2.23 - 10.06) and ≥ 80 years (HR 22.77; 95%CI 9.91 - 52.28) than in patients < 40 years of age; in male patients than in female patients (HR 1.38; 95%CI 1.07 - 1.78); and in patients with one (adjusted HR 1.95; 95%CI 1.5 - 2.53), two (adjusted HR 4.49; 95%CI 3.27 - 6.16) or more than two comorbidities (adjusted HR 4.99; 95%CI 2.62 - 9.5) than in patients with no comorbidities. Neither vasoactive medication use nor mechanical ventilation resulted in statistically significant results.
Conclusion: For Dutch COVID-19 intensive care unit patients, most deaths occurred during their hospital stay. For hospital survivors, the crude 12-month mortality rate was low. Patient age (older than 60), sex and the number of comorbidities were associated with a greater hazard of death at 12 months after hospital discharge, whereas mechanical ventilation and vasoactive medication were not.
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