Postprandial inflammation across the aging spectrum

Abstract

Objectives

Postprandial inflammation post-high-fat meals may be linked to cardiovascular disease (CVD). CVD incidence increases with age; however, whether older adults experience greater postprandial inflammation remains unclear. We examined whether analyzing age categorically versus continuously influenced relationships between age and postprandial inflammatory measures.

Design

Cross-sectional.

Setting

Laboratory for Applied Nutrition and Exercise Science at Oklahoma State University (Stillwater, OK, USA).

Participants

56 apparently healthy adults ages 20–69 years.

Measurements

We measured interleukin (IL)-1β, IL-6, IL-8, IL-10, and tumor necrosis factor (TNF)-α at baseline, 2-, 4-, and 6 -hs post-high-fat meal (9 kcal/kg; 70% fat). Data were examined in the full sample with paired t-tests (baseline to peak), by pre-defined age groups (i.e., 18–35, 36–49, 50–59, 60–69) using ANCOVA, and continuously using linear regression.

Results

Across the full sample, IL-1β, IL-6, and IL-8 increased after the high-fat meal (p’s≤0.018). Cytokine differences post-high-fat meal by age category were generally not observed. However, age was positively associated with IL-6 incremental AUC when examined continuously (b = 0.029; p = 0.010).

Conclusion

These data suggest increasing age is linked to a greater IL-6 response to a high-fat meal. Further, examining age continuously may have greater utility when studying aging and postprandial inflammation.

Registration

N/A (secondary analysis)